有哪些信誉好的足球投注网站hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells过氧化氢改变拼接的可溶性guanylyl环化酶和选择性剪接的调节表达监管机构在人类癌症细胞.pdfVIP
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hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells过氧化氢改变拼接的可溶性guanylyl环化酶和选择性剪接的调节表达监管机构在人类癌症细胞
Hydrogen Peroxide Alters Splicing of Soluble Guanylyl Cyclase and Selectively Modulates Expression of Splicing Regulators in Human Cancer Cells 2 2 1 1 3 1 Gilbert J. Cote , Wen Zhu , Anthony Thomas , Emil Martin , Ferid Murad , Iraida G. Sharina * 1 Department of Internal Medicine/Cardiology, University of Texas Medical School, UTHealth, Houston, Texas, United States of America, 2 Department of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center, Houston, Texas, United States of America, 3 Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC, United States of America Abstract Background: Soluble guanylyl cyclase (sGC) plays a central role in nitric oxide (NO)-mediated signal transduction in the cardiovascular, nervous and gastrointestinal systems. Alternative RNA splicing has emerged as a potential mechanism to modulate sGC expression and activity. C-a1 sGC is an alternative splice form that is resistant to oxidation-induced protein degradation and demonstrates preferential subcellular distribution to the oxidized environment of endoplasmic reticulum (ER). Methodology/Principal Findings: Here we report that splicing of C-a1 sGC can be modulated by H O treatment in BE2 2 2 neuroblastoma and MDA-MD-468 adenocarcinoma human cells. In addition, we show that the H2O2 treatment of MDA-MD- 468 cells selectively decreases protein levels of PTBP1 and hnRNP A2/B1 splice factors identified as potential a1 gene splicing regulators by in silico analysis. We further demonstrate that down-regulation of
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