hyaluronate fragments reverse skin atrophy by a cd44-dependent mechanism透明质酸盐片段反向cd44-dependent皮肤萎缩的机制.pdfVIP

PLoS MEDICINE Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism ¨ 1* 1 1 1 1 1 1 Gurkan Kaya , Christian Tran , Olivier Sorg , Raymonde Hotz , Denise Grand , Pierre Carraux , Liliane Didierjean , 2 1 Ivan Stamenkovic , Jean-Hilaire Saurat 1 Department of Dermatology, University of Geneva, Geneva, Switzerland, 2 Institute of Pathology, University of Lausanne, Lausanne, Switzerland Funding: This work was supported A B S T R A C T by the University of Geneva Dermatology Fund and Genderm Research Program to GK and JHS, and Swiss National Science Background Foundation grant 3100-65090-01 and the Molecular Oncology Skin atrophy is a common manifestation of aging and is frequently accompanied by National Centre for Competence in ulceration and delayed wound healing. With an increasingly aging patient population, Research (NCCR) to IS. The funders had no role in study design, data management of skin atrophy is becoming a major challenge in the clinic, particularly in light of collection and analysis, decision to the fact that there are no effective therapeutic options at present. publish, or preparation of the manuscript. Methods and Findings Competing Interests: The authors have declared that no competing Atrophic skin displays a decreased hyaluronate (HA) content and expression of the major cell- interests exist. surfa