hiv impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites艾滋病削弱乳素调理吞噬清除疟疾寄生虫.pdfVIP

PLoS MEDICINE HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites 1 1,2,3 1 1 4 4 5 Jessica Keen , Lena Serghides , Kodjo Ayi , Samir N. Patel , John Ayisi , Anne van Eijk , Richard Steketee , Venkatachalam Udhayakumar5, Kevin C. Kain1,2,3* 1 Faculty of Medicine, University of Toronto, Toronto, Canada, 2 McLaughlin-Rotman Centre, McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Canada, 3 University Health Network, Toronto, Canada, 4 Center for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya, 5 Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Funding: This study was funded in A B S T R A C T part by a Canadian Institutes of Health Research (CIHR) Team Grant in Malaria (KCK), CIHR MT-13721 (KCK), Genome Canada through the Background Ontario Genomics Institute (KCK), Canadian Genetics Disease Network, Primigravid (PG) women are at risk for pregnancy-associated malaria (PAM). Multigravid (MG) and CIHR Canada Research Chair, women acquire protection against PAM; however, HIV infection impairs this protective KCK. The funders had no role in study design, data collection and response. Protection against PAM is associated with the production of IgG specific for variant analysis, decision to publish, or surface antigens (VSA-PAM) expressed by chondroitin sulfate A (CSA)-adhering parasitized preparation of the manuscript. erythrocytes (PEs). We hypothesized