有哪些信誉好的足球投注网站hiv envelope gp120 activates lfa-1 on cd4 t-lymphocytes and increases cell susceptibility to lfa-1-targeting leukotoxin (ltxa)艾滋病毒包膜gp120激活lfa-1 cd4淋巴细胞,增加细胞对lfa-1-targeting白细胞毒素(ltxa).pdfVIP
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hiv envelope gp120 activates lfa-1 on cd4 t-lymphocytes and increases cell susceptibility to lfa-1-targeting leukotoxin (ltxa)艾滋病毒包膜gp120激活lfa-1 cd4淋巴细胞,增加细胞对lfa-1-targeting白细胞毒素(ltxa)
HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA) Catarina E. Hioe1*, Michael Tuen 1, Gaia Vasiliver-Shamis2, Yelina Alvarez 1, Kathleen C. Prins 1,2, Sagarika 1 ´ 3 4 2 5,6 Banerjee , Arthur Nadas , Michael W. Cho , Michael L. Dustin , Scott C. Kachlany 1 Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America, 2 Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America, 3 Department of Environmental Medicine, New York University School of Medicine, New York, New York, United States of America, 4 Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America, 5 Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America, 6 Actinobac Biomed, Incorporated, North Brunswick, New Jersey, United States of America Abstract The cellular adhesion molecule LFA-1 and its ICAM-1 ligand play an important role in promoting HIV-1 infectivity and transmission. These molecules are present on the envelope of HIV-1 virions and are integral components of the HIV virological synapse. However, cellular activation is required to convert LFA-1 to the active conformation that has high affinity binding for ICAM-1. This study evaluates whether such activation can be induced by HIV itself. The data sh
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