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human keratinocytes are vanilloid resistant人类角质化细胞草酸抗性
Human Keratinocytes Are Vanilloid Resistant ´ ´ 1 ´ ´ 2 ´ ´ 2 ´ 1 ´ ´ 1 ´ ´ 1 ´ Laszlo Pecze , Kornelia Szabo , Marta Szell , Katalin Josvay , Krisztian Kaszas , Erzsebet Kusz , Tamas 1,3 ´ 4 ´ 4 ´ ´ 4 ´ 5 1 ´ ´ 1,6 Letoha , Janos Prorok , Istvan Koncz , Andras Toth , Lajos Kemeny , Csaba Vizler , Zoltan Olah * 1 Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary, 2 Dermatological Research Group of the Hungarian ¨ Academy of Sciences, Szeged, Hungary, 3 Department of Medical Chemistry, University of Szeged, Albert Szent-Gyorgyi Medical and Pharmaceutical Center, Szeged, ¨ Hungary, 4 Department of Pharmacology and Pharmacotherapy, University of Szeged, Albert Szent-Gyorgyi Medical and Pharmaceutical Center, Szeged, Hungary, ¨ 5 Department of Dermatology and Allergology, University of Szeged, Albert Szent-Gyorgyi Medical and Pharmaceutical Center, Szeged, Hungary, 6 Acheuron Ltd, Szeged, Hungary Abstract Background: Use of capsaicin or resiniferatoxin (RTX) as analgesics is an attractive therapeutic option. RTX opens the cation channel inflammatory pain/vanilloid receptor type 1 (TRPV1) permanently and selectively removes nociceptive neurons by Ca
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