human and murine kidneys show gender- and species-specific gene expression differences in response to injury人类和小鼠肾脏显示性别和种特异的基因表达的差异反应损伤.pdfVIP

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human and murine kidneys show gender- and species-specific gene expression differences in response to injury人类和小鼠肾脏显示性别和种特异的基因表达的差异反应损伤.pdf

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human and murine kidneys show gender- and species-specific gene expression differences in response to injury人类和小鼠肾脏显示性别和种特异的基因表达的差异反应损伤

Human and Murine Kidneys Show Gender- and Species- Specific Gene Expression Differences in Response to Injury 1 1 1 1 1 Han Si , Ramandeep S. Banga , Pinelopi Kapitsinou , Manjunath Ramaiah , Janis Lawrence , Ganesh 1 1 4 1 2 2 Kambhampati , Antje Gruenwald , Erwin Bottinger , Daniel Glicklich , Vivian Tellis , Stuart Greenstein , 3 3 5 1 David B. Thomas , James Pullman , Melissa Fazzari , Katalin Susztak * 1 Department of Medicine/Nephrology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Surgery, Montefiore Medical Center, Bronx, New York, United States of America, 3 Department of Pathology, Montefiore Medical Center, Bronx, New York, United States of America, 4 Department of Medicine/Nephrology, Mount Sinai School of Medicine, New York, United States of America, 5 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America Abstract The incidence of End Stage Renal Disease (ESRD) is approximately 50% higher in men than women. In order to understand the molecular basis of this gender disparity, we examined sex specific gene expression patterns in control and diseased, human and murine kidney samples. Using the Affymetrix platform we performed comprehensive gene expression analysis on 42 microdissected human kidney samples (glomeruli and tubules). We identified 67 genes with gender biased expression in healthy human kidneys and 24 transcripts in diseased male and female human kidneys. Similar analysis performed in