high-density lipoprotein (hdl) particle subpopulations in heterozygous cholesteryl ester transfer protein (cetp) deficiency maintenance of antioxidative activity高密度脂蛋白(hdl)粒子亚种群在杂合的胆甾醇酯转运蛋白(cetp)缺乏维护的抗氧化活性.pdfVIP

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high-density lipoprotein (hdl) particle subpopulations in heterozygous cholesteryl ester transfer protein (cetp) deficiency maintenance of antioxidative activity高密度脂蛋白(hdl)粒子亚种群在杂合的胆甾醇酯转运蛋白(cetp)缺乏维护的抗氧化活性.pdf

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high-density lipoprotein (hdl) particle subpopulations in heterozygous cholesteryl ester transfer protein (cetp) deficiency maintenance of antioxidative activity高密度脂蛋白(hdl)粒子亚种群在杂合的胆甾醇酯转运蛋白(cetp)缺乏维护的抗氧化活性

High-Density Lipoprotein (HDL) Particle Subpopulations in Heterozygous Cholesteryl Ester Transfer Protein (CETP) Deficiency: Maintenance of Antioxidative Activity 1 ¤ 2 1,3,4 2 1,3,4 Sandrine Chantepie * , Andrea E. Bochem , M. John Chapman , G. Kees Hovingh , Anatol Kontush 1 INSERM UMRS 939, Pitie-Salpetriere University Hospital, Paris, France, 2 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, ´ ´ ` 3 Department of Scientific Research, University Pierre and Marie Curie - Paris 6, Paris, France, 4 AP-HP, Groupe hospitalier Pitie-Salpetriere, Paris, France Abstract Cholesteryl ester transfer protein (CETP) deficiency causes elevated high-density lipoprotein-cholesterol (HDL-C) levels; its impact on HDL functionality however remains elusive. We compared functional and compositional properties of HDL derived from 9 Caucasian heterozygous CETP mutation carriers (splice-site mutation in intron 7 resulting in premature truncation) with those of 9 age- and sex-matched normolipidemic family controls. As expected, HDL-C levels were increased 1.5-fold, and CETP mass and activity were decreased by 231% and 238% respectively, in carriers versus non-carriers. HDL particles from carriers were enriched in CE (up to + 19%, p,0.05) and depleted of triglycerides (TG; up to 254%, p,0.01), resulting in a reduced TG/CE ratio (up to 2.5-fold, p,0.01). In parallel, the apoA-I content was increased in HDL from carriers (up to +22%, p,0.05). Both the total HDL fraction and small, dense HDL3 particles from CETP-deficient subject