有哪些信誉好的足球投注网站human anti-aβ iggs target conformational epitopes on synthetic dimer assemblies and the ad brain-derived peptide人类anti-aβ目标构象表位免疫球蛋白合成二聚体组件和ad脑源性肽.pdfVIP
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human anti-aβ iggs target conformational epitopes on synthetic dimer assemblies and the ad brain-derived peptide人类anti-aβ目标构象表位免疫球蛋白合成二聚体组件和ad脑源性肽
Human Anti-Ab IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide 1 2 2 2 3 Alfred T. Welzel , Angela D. Williams , Helen P. McWilliams-Koeppen , Luis Acero , Alfred Weber , 4 1,4 3 3 5 Veronika Blinder , Alex Mably , Sebastian Bunk , Corinna Hermann , Michael A. Farrell , 3 3 1,4 2 1,2,4 Hartmut J. Ehrlich , Hans P. Schwarz , Dominic M. Walsh , Alan Solomon , Brian O’Nuallain * 1The Conway Institute, University College Dublin, Belfield, Dublin, Republic of Ireland, 2 Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America, 3 Baxter BioScience, Vienna, Austria, 4 The Laboratory of Neurodegenerative Research, Brigham and Women’s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, United States of America, 5 Dublin Brain Bank, Pathology Department, Beaumont Hospital, Dublin, Ireland Abstract Soluble non-fibrillar assemblies of amyloid-beta (Ab) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD). Anti-Ab immunotherapy is a promising and advanced therapeutic strategy, but the precise Ab species to target is not yet known. Previously, we and others have shown that natural human IgGs (NAbs) target diverse Ab conformers and have therapeutic potential. We now demonstrate that these antibodies bound with nM
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