human bat possesses molecular signatures that resemble beigebrite cells人类蝙蝠拥有类似beigebrite细胞的分子特征.pdfVIP

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells 1 1 1 1 1 1 Louis Z. Sharp , Kosaku Shinoda , Haruya Ohno , David W. Scheel , Emi Tomoda , Lauren Ruiz , 2 3 3 2 1 Houchun Hu , Larry Wang , Zdena Pavlova , Vicente Gilsanz , Shingo Kajimura * 1 UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Radiology, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America, 3 Department of Pathology, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America Abstract Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: ‘‘classical’’ brown adipocytes develop during the prenatal stage whereas ‘‘beige’’ or ‘‘brite’’ cells that reside in white adipose tissue (WAT) develop during the postnatal stage in response to chronic cold or PPARc agonists. Beige cells’ inducible characteristics make them a promising therapeutic target for obesity treatment, however, the relevance of this cell type in humans remains unknown. In the present study, we determined the gene signatures that were unique to classical brown adipocytes and to beige cells induced by a specific PPARc agonist rosiglitazone in mice. Subsequently we applied the