有哪些信誉好的足球投注网站hos2 and hda1 encode histone deacetylases with opposing roles in candida albicans morphogenesishos2 hda1编码组蛋白去乙酰酶抑制剂和白色念珠菌形态发生对立的角色.pdfVIP
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hos2 and hda1 encode histone deacetylases with opposing roles in candida albicans morphogenesishos2 hda1编码组蛋白去乙酰酶抑制剂和白色念珠菌形态发生对立的角色
HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis Lucia F. Zacchi*, Wade L. Schulz, Dana A. Davis Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, United States of America Abstract Epigenetic mechanisms regulate the expression of virulence traits in diverse pathogens, including protozoan and fungi. In the human fungal pathogen Candida albicans, virulence traits such as antifungal resistance, white-opaque switching, and adhesion to lung cells are regulated by histone deacetylases (HDACs). However, the role of HDACs in the regulation of the yeast-hyphal morphogenetic transitions, a critical virulence attribute of C. albicans, remains poorly explored. In this study, we wished to determine the relevance of other HDACs on C. albicans morphogenesis. We generated mutants in the HDACs HOS1, HOS2, RPD31, and HDA1 and determined their ability to filament in response to different environmental stimuli. We found that while HOS1 and RPD31 have no or a more limited role in morphogenesis, the HDACs HOS2 and HDA1 have opposite roles in the regulation of hyphal formation. Our results demonstrate an important role for HDACs on the regulation of yeast-hyphal transitions in the human pathogen C. albicans. Citation: Zacchi LF, Schulz WL, Davis DA (2010) HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis. PLoS ONE 5(8): e12171. doi:10.1371/journal.pone.0012171 Editor: Andy Alspaugh, Duke University, United States of America Received April 15, 2010; Accepted July 14, 2010; Published August 13, 2010 Copyright: 2010 Zacchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and sou
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