heritability and demographic analyses in the large isolated population of val borbera suggest advantages in mapping complex traits genes大型孤立的人口的遗传和人口分析val borbera建议映射复杂性状的基因优势.pdfVIP

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heritability and demographic analyses in the large isolated population of val borbera suggest advantages in mapping complex traits genes大型孤立的人口的遗传和人口分析val borbera建议映射复杂性状的基因优势.pdf

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heritability and demographic analyses in the large isolated population of val borbera suggest advantages in mapping complex traits genes大型孤立的人口的遗传和人口分析val borbera建议映射复杂性状的基因优势

Heritability and Demographic Analyses in the Large Isolated Population of Val Borbera Suggest Advantages in Mapping Complex Traits Genes 1. 1. 1 1 1 1 Michela Traglia , Cinzia Sala , Corrado Masciullo , Valeria Cverhova , Francesca Lori , Giorgio Pistis , 1,4 2 2 3 3 7 Silvia Bione , Paolo Gasparini , Sheila Ulivi , Marina Ciullo , Teresa Nutile , Emanuele Bosi , Marcella 8 8 8 1 1 Sirtori , Giovanna Mignogna , Alessandro Rubinacci , Iwan Buetti , Clara Camaschella , Enrico Petretto5,6, Daniela Toniolo1,4* 1 Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano Italy, 2 Medical Genetics, Department of Laboratory Medicine, Institute for Maternal and Child Health IRCCS-Burlo Garofolo, Trieste, Italy, 3 Institute of Genetics and Biophysics’’Adriano Buzzati-Traverso’’, CNR, Napoli, Italy, 4 Institute of Molecular Genetics-CNR, Pavia, Italy, 5 MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, London, United Kingdom, 6 Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, London, United Kingdom, 7 Department of Internal Medicine, Diabetes Endocrinology Unit, San Raffaele Scientific Institute, Milano, Italy, 8 Bone Metabolic Unit, San Raffaele Scientific Institute, Milano, Italy Abstract Background: Isolated populations are a useful resource for mapping complex traits due to shared stable environment, reduced genetic complexity and extended Linkage Disequilibrium (LD) compared to the gene