hepcidin expression in iron overload diseases is variably modulated by circulating factorshepcidin表达铁过载疾病不定地调制循环因素.pdfVIP

Hepcidin Expression in Iron Overload Diseases Is Variably Modulated by Circulating Factors 1 1 2 2 3 Giulia Ravasi , Sara Pelucchi , Paola Trombini , Raffaella Mariani , Naohisa Tomosugi , Giulia 1 1 4 4 3 5 Litta Modignani , Matteo Pozzi , Elizabeth Nemeth , Tomas Ganz , Hisao Hayashi , Donatella Barisani , Alberto Piperno1,2,6* 1 Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza, Italy, 2 Centre for Diagnosis and Treatment of Hemochromatosis, S. Gerardo Hospital, Monza, Italy, 3 Division of Nephrology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan, 4 Department of Medicine and Pathology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, California, United States of America, 5 Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy, 6 Consortium of Human Molecular Genetics, Monza, Italy Abstract Hepcidin is a regulatory hormone that plays a major role in controlling body iron homeostasis. Circulating factors (holotransferrin, cytokines, erythroid regulators) might variably contribute to hepcidin modulation in different pathological conditions. There are few studies analysing the relationship between hepcidin transcript and related protein expression profiles in humans. Our aims were: a. to measure hepcidin expression at either hepatic, serum and urinary level in three paradigmatic iron overload conditions (hemochromatosis, thalassemia and dysmetabolic iron overload syndrome) and in controls; b. to measure mR