genetic variations in plasma circulating dna of hbv-related hepatocellular carcinoma patients predict recurrence after liver transplantation遗传变异与乙型肝炎病毒有关的肝癌患者的血浆循环dna预测肝移植后复发.pdfVIP

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genetic variations in plasma circulating dna of hbv-related hepatocellular carcinoma patients predict recurrence after liver transplantation遗传变异与乙型肝炎病毒有关的肝癌患者的血浆循环dna预测肝移植后复发.pdf

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genetic variations in plasma circulating dna of hbv-related hepatocellular carcinoma patients predict recurrence after liver transplantation遗传变异与乙型肝炎病毒有关的肝癌患者的血浆循环dna预测肝移植后复发

Genetic Variations in Plasma Circulating DNA of HBV- Related Hepatocellular Carcinoma Patients Predict Recurrence after Liver Transplantation 1. 1. 1,2,3. 1 1 1 1 Jie Hu , Zheng Wang , Jia Fan , Zhi Dai , Yi-Feng He , Shuang-Jian Qiu , Xiao-Wu Huang , Jian 1 1 1 1 1 1 1 Sun , Yong-Sheng Xiao , Kang Song , Ying-Hong Shi , Qi-Man Sun , Xin-Rong Yang , Guo-Ming Shi , Lei 1 1 1 1 1,2 1,2,3 Yu , Guo-Huan Yang , Zhen-Bin Ding , Qiang Gao , Zhao-You Tang , Jian Zhou * 1 Liver Cancer Institute, Zhong Shan Hospital, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai Key Laboratory for Organ Transplantation, Shanghai, People’s Republic of China, 2 Institute of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China, 3 Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghi, People’s Republic of China Abstract Background: Recurrence prediction of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) present a great challenge because of a lack of biomarkers. Genetic variations play an important role in tumor development and metastasis. Methods: Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorph