genetics of ischaemic stroke among persons of non-european descent a meta-analysis of eight genes involving ～ 32,500 individuals缺血性中风的基因在非欧洲血统的人一个荟萃分析的八个基因涉及~ 32500人.pdfVIP

PLoS MEDICINE Genetics of Ischaemic Stroke among Persons of Non-European Descent: A Meta-Analysis of Eight Genes Involving ; 32,500 Individuals 1 2 2 2 3 1* Roshan Ariyaratnam , Juan P Casas , John Whittaker , Liam Smeeth , Aroon D Hingorani , Pankaj Sharma 1 Imperial College Cerebrovascular Research Unit (ICCRU), Department of Clinical Neuroscience, Hammersmith Hospitals and Imperial College, London, 2 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, 3 Centre for Clinical Pharmacology, University College, London Funding: This work was funded by A B S T R A C T the Stroke Association (UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the Background manuscript. Ischaemic stroke in persons of European descent has a genetic basis, but whether the stroke- Competing Interests: The authors susceptibility alleles, the strength of any association, and the extent of their attributable risks have declared that no competing are the same in persons of non-European descent remains unanswered. Whether ethnicity itself interests exist. has a relevant or substantial contribution on those effect estimates is controversial. Academic Editor: Peter Sandercock, Comparative analyses between the ethnic groups may allow general conclusions to be drawn Western General Hospital, United Kingdom about polygenic disorders. Citation: Ariyaratnam R, Casas JP, Whittaker J, Smeeth L, Hingorani AD, M