gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney基因表达分析揭示了细胞周期及着丝粒基因参与肾脏缺血再灌注损伤和早期发展.pdfVIP

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2017-09-01 发布于上海
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gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney基因表达分析揭示了细胞周期及着丝粒基因参与肾脏缺血再灌注损伤和早期发展.pdf

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gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney基因表达分析揭示了细胞周期及着丝粒基因参与肾脏缺血再灌注损伤和早期发展

Gene Expression Analysis Reveals the Cell Cycle and Kinetochore Genes Participating in Ischemia Reperfusion Injury and Early Development in Kidney 1. ´ 2,4. 3,4 3,4 1 Tae-Min Kim , Victoria Ramırez , Jonatan Barrera-Chimal , Norma A. Bobadilla , Peter J. Park , Vishal S. Vaidya2,5* 1 Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Renal Division, Department of Medicine, Brigham and ´ Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, ´ ´ ´ ´ ´ Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, 4 Departamento de Nefrologıa y Metabolismo Mineral, Instituto Nacional de Ciencias Medicas y Nutricion ´ Salvador Zubiran, Mexico City, Mexico, 5 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America Abstract Background: The molecular mechanisms that mediate the ischemia-reperfusion (I/R) injury in kidney are not completely understood. It is also largely unknown whether such mechanisms overlap with those governing the early development of kidney. Methodology/Principal Findings: We performed gene expression analysis to investigate the transcriptome changes during