有哪些信誉好的足球投注网站gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for down syndrome screening基因表达分析在一个小鼠模型识别胎儿肝脏和placenta-derived唐氏综合症筛查潜在生物标志物.pdfVIP
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gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for down syndrome screening基因表达分析在一个小鼠模型识别胎儿肝脏和placenta-derived唐氏综合症筛查潜在生物标志物
Gene Expression Profiling in a Mouse Model Identifies Fetal Liver- and Placenta-Derived Potential Biomarkers for Down Syndrome Screening 1 . 1. 1 2 Jeroen L. A. Pennings * , Wendy Rodenburg , Sandra Imholz , Maria P. H. Koster , Conny T. M. van 1 3 2 1 Oostrom , Timo M. Breit , Peter C. J. I. Schielen , Annemieke de Vries 1 Laboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 2 Laboratory for Infectious Diseases and Perinatal Screening (LIS), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, 3 MicroArray Department (MAD), University of Amsterdam (UvA), Amsterdam, The Netherlands Abstract Background: As a first step to identify novel potential biomarkers for prenatal Down Syndrome screening, we analyzed gene expression in embryos of wild type mice and the Down Syndrome model Ts1Cje. Since current Down Syndrome screening markers are derived from placenta and fetal liver, these tissues were chosen as target. Methodology/Principal Findings: Placenta and fetal liver at 15.5 days gestation were analyzed by microarray profiling. We confirmed increased expression of genes located at the trisomic chromosomal region. Overall, between the two genotypes more differentially expressed genes were found in fetal liver than in placenta. Furthermore, the fetal liver data are in line with the hematological aberrations found in humans with Down Syndrome as well as Ts1Cje mice. Together, we found 25 targets that are predicted (by Gene Ontology, UniProt, or the Human Plasma Proteome project) to be de
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