foxp4 is dispensable for t cell development, but required for robust recall responsesfoxp4 t细胞发展是可有可无的,但需要健壮的召回响应.pdfVIP

Foxp4 Is Dispensable for T Cell Development, but Required for Robust Recall Responses 1 1 1 1 2 Karla R. Wiehagen , Evann Corbo-Rodgers , Shanru Li , Elizabeth S. Staub , Christopher A. Hunter , 1 1 Edward E. Morrisey , Jonathan S. Maltzman * 1 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 2 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract Transcription factors regulate T cell fates at every stage of development and differentiation. Members of the Foxp family of forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for T regulatory cell ¨ generation and function, and Foxp1 is necessary for generation and maintenance of naıve T cells. Foxp4, an additional member of the Foxp family, is highly homologous to Foxp1 and has been shown to dimerize with other Foxp proteins. We report the initial characterization of Foxp4 in T lymphocytes. Foxp4 is expressed in both thymocytes and peripheral CD4+ and CD8+ T cells. We used a CD4Cre mediated approach to evaluate the cell autonomous role for Foxp4 in murine T lymphocytes. T cell development, peripheral cellularity and cell surface phenotype are normal in the absence of Foxp4. Furthermore, Foxp3+ ¨ T regula