有哪些信誉好的足球投注网站foxp3 and il-10 expression correlates with parasite burden in lesional tissues of post kala azar dermal leishmaniasis (pkdl) patientsfoxp3和il - 10表达与寄生虫负担lesional组织后黑热病患者皮肤利什曼病(pkdl).pdfVIP
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foxp3 and il-10 expression correlates with parasite burden in lesional tissues of post kala azar dermal leishmaniasis (pkdl) patientsfoxp3和il - 10表达与寄生虫负担lesional组织后黑热病患者皮肤利什曼病(pkdl)
Foxp3 and IL-10 Expression Correlates with Parasite Burden in Lesional Tissues of Post Kala Azar Dermal Leishmaniasis (PKDL) Patients 1 1¤ 1 2 1 Gajendra Kumar Katara , Nasim Akhtar Ansari , Sandeep Verma , V. Ramesh , Poonam Salotra * 1 Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India, 2 Department of Dermatology, Safdarjung Hospital, New Delhi, India Abstract Background: Post kala-azar dermal leishmaniasis (PKDL), a sequel to visceral leishamaniasis (VL) in 5–15% cases, constitutes a parasite reservoir important in disease transmission. The precise immunological cause of PKDL outcome remains obscure. However, overlapping counter regulatory responses with elevated IFN-c and IL-10 are reported. Methodology/Principal Findings: Present study deals with ex-vivo mRNA and protein analysis of natural regulatory T cells (nTreg) markers (Foxp3, CD25 and CTLA-4) and IL-10 levels in lesion tissues of PKDL patients at pre and post treatment stages. In addition, correlation of nTreg markers and IL-10 with parasite load in tissue lesions was investigated. mRNA levels of nTreg markers and IL-10 were found significantly elevated in pre-treatment PKDL cases compared to controls (Foxp3, P = 0.0009; CD25 CTLA-4, P,0.0001; IL-10, P,0.0001), and were restored after treatment. Analysis of nTreg cell markers and IL-10 in different clinical manifestations of disease revealed elevated levels in nodular lesions compared to macules/ papules. Further, Foxp3, CD25 and IL-10 mRNA levels directly correlated with parasite load in lesions tissues. Conclusion/Significance: Data demonstrated accumulation of nTreg cells in infected tissue and a correlation of both IL-10 and nTreg levels with parasite burden su
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