Cellyzyme(蘑菇提取物)美白、祛皱疗效及安全性观察.docVIP

Cellyzyme(蘑菇提取物)美白、祛皱疗效及安全性观察[摘要]目的：观察含有Celluzyme（蘑菇提取物）的美白换肤面膜的美白、祛皱作用及安全性。方法：招募30名健康受试者，左右侧面部随机分为治疗侧（使用含Celluzyme的面膜）及对照侧（不用面膜）。于使用面膜前、后不同时间点，检测皮肤颜色及角质层含水量，并由医师及受试者各自进行疗效主观评分。结果：治疗侧L差值（皮肤亮度）显著高于对照侧，而*a差值（反应皮肤的红斑情况）、含水量差值则无明显区别。医师及受试者的主观评分均认定面膜可使皮肤美白、毛孔细致、皱纹减少。结论：美白换肤面膜可安全而有效地改善皮肤色泽和质地。 [关键词]面膜；美白；换肤；化学剥脱 [中图分类号]R758[文献标识码]A[文章编号]1008-6455（2008）10-1500-03 The efficacy and safety of celluzyme (extract of mushroom) facial mask XU Yuan-yuan,LI Yuan-hong,WU Yan,YANG Xue-song,DONG Guang-hui, GENG Long,GAO Xing-hua,CHEN Hong-duo (Department of Dermatology,the First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning,China) Abstract:Objective To observe the efficay and safety of celluzyme (extract of mushroom) facial mask. on skin color, pore size, and wrinkles. Methods Thirty healthy volunteers were recruited. One side of face was treated with the facial mask twice a week for a consecutive 4 weeks, according to a randomisation table. The other side was spared and observed as the self control. Before and after each procedure, skin color and water content were measured with spectrophotometer (L: skin lightness; a: erythema) and corneometer, individually. The global assessment were performed both by a blinded dermatologist and by all the volunteers.ResultsThe mean change of L value of the treated side was significantly higher than that of the control side. However, the mean *a value and water content did not change differently between the two sides. Both the dermatologist and the volunteers assessed that the celluzyme facial mask could whiten the skin, shrink the pore, and reduce the wrinkle, in the slight to moderate extent. ConclusionCelluzyme facial mask could effectively and safely improve skin color and texture. Key words:mask;whitening and brightening;resurfacing;chemical peel 化学剥脱术是用一种或几种化学物质作用于皮肤，通过多种途径达到皮肤重建的美容方法。此方法疗效显著，但也可能出现一些副作用，如红斑、水肿、色素沉着[1]、色素脱失[2]、瘢痕，甚至心律不齐[3]等。近年来，越来越多的人热衷于用损伤小、安全且适于家庭使用的物质来改善皮肤。最近，强生公司研发了一种来