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家兔实验性肺水肿及治疗探讨(Experimental pulmonary edema and its treatment in rabbits)
家兔实验性肺水肿及治疗探讨(Experimental pulmonary edema and its treatment in rabbits)
Experimental pulmonary edema and its treatment in rabbits
Cai Chaonong, Xie Yi, Chen Jinjin, Hou Weijian
Tutor Zhu Banghao
Department of clinical 98 (10), Zhongshan Medical University, 510089
Abstract
Pulmonary edema refers to the infiltration of pulmonary fluid into the interstitium and alveoli of the lung. The pathological state and clinical manifestations of pulmonary extravascular fluid volume increased for sudden onset, dyspnea, cyanosis, cough, red or pink foam sputum, pulmonary diffuse rales, X-ray manifestations in two lung butterfly flake fuzzy shadow, is one of the clinical emergency. The purpose of this study is to replicate the pulmonary edema in acute rabbits, and to understand the manifestation and mechanism of pulmonary edema, and further to investigate the drug treatment of pulmonary edema. The experiment was divided into four groups: 1 experimental groups, 1 control groups and 2 treatment groups. Each group started with tracheal intubation for rabbits, and recorded the whole process respiration curve with two guides. According to the weight quickly from the ear vein infusion of normal saline (180~200 drops / minute), close to the drop, according to different groups to give filling respectively, breathing, anisodamine, diuretic, and observe the changes of respiration and the respiratory sounds auscultation in change. Finally, rabbits were killed by bloodletting, and the main bronchi were ligated and ligated. The lungs were weighed out and observed. Finally, the lung coefficient = lung weight (g) / body weight (kg) was calculated, and the experimental groups were compared.
Key words: pulmonary edema, rabbits, trachea intubation, anisodamine, diuresis, lung coefficient
1 materials and methods
Material: 1.1 rabbits (4 rabbits), baby, balance, tracheal intubation and two physiological guide apparatus, infusion device, small neck surgical instruments, stethoscope, saline, surgery, ep
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