比索洛尔和美托洛尔治疗非杓型高血压患者临床观察_邝健.pdfVIP

DO I :10.14164/j .cnki .cn11 -5581/r .2009.20.054 ·12 · 2009 10 3 20 　ChinJModDrugApp,lOt2009, Vo.l3, No.20 邝健　黄裕立　梁华琼 【】　　。　 56 ,, (n=29 ) 2.5 ～5 mg, (n= 27 )50 ～100 mg 8 24 h。　 8 , SBP、DBP HR (P0.01 )。 8 89.6% 74.1%(P0.05 )。 ABPM, dMSBP, dMDBP, nMSBPnMDBP, MSBP, MDBP (P0.05 )。 (P0.05 ), , (P0.05 )。, 15 (5 1.7%), 8 (29.6%)。　。 【】　;;; Clinialeffetsofbisoprololinomparisonwithmetoprololinhypertensivepatientswithnon-dipperpat- ternofbloodpressure　KUANGJiang, HUANGYu-,liLIANGHua-qiong.DepartmentofHypertension, the FirstAffiliatedHospita,lSunYat-senUniversit,yDongshandivisionGuangzhou510080, China 【Abstrat】　Objetive　Toexploretheeffiayofbisoprololinomparisonwithmetoprololinhyperten- sivepatientswithnon-dipperpatternofbloodpressure.Method　Randomized, parallelgroup:sBisoprolol group(n=29 ), treatedwithbisoprolol2.5 mgto5 mgdail,yMetoprololgroup(n=27 ), treatedwithmetoprolol 50 mgto100 mgdaily.Evaluationoftheresultof8 weeks treatmen,tandthehangeofABPM.Results　The SBP, DBPandHRdereasedsignifiantlyintwogroupsafter8 weeks treamtent(P0.0 1).Thetotaleffiay rateforBPdereaseafter8 week streamtentofbisoprololgroupis89.6%, thatofmetoprololgroupis74.1% (P0.05 ).TheresultofABPMshowsthedMSBP, dMDBP, nMSBPnMDBP, MSBPandMDBPdereasedsig- nifiantlyinbothgroupsafter8 weeks treamtent(P0.05 ).Thereisnoothersignifiantdifferenebetween twogroupsforthedayBPderease(P0.05 ), butabettereffiayofbisoprololthanmetoprololinthederea- singofnightBP(P0.05 ).After8 weeks treamten,tthereare15 hypertensivepatientswithnon-dipperpat- ternofbloodpressurehangeintodipperpatterninbisoprololgroup, and8 patientsinmetoprololgroup.Con- lusion　Bisoprololhassatisfyingeffetinhypertensivepatientswithnon-dipperpatternofbloodpressure. 【Keywords】　Bisoprolo;lMetoprolo;lDipperpatternandnon-dipperpatternofbloodpressure;Essen- tialhypertension 　　, 2007 2 2009 2 20 ～70 , 、、 1 ～2 98