比索洛尔与美托洛尔治疗高血压病疗效的对比研究.pdfVIP

维普资讯 · 340 · 高血压杂志 ChineseJournalofHypertension 2003 Aug 11(4) 文章编号：1006—2866(2003)04-0340—05 中图分类号：R544．1；R972 文献标识码：A 比索洛尔与美托洛尔治疗高血压病疗效的对比研究 临床治疗协作组 。 EffectBisoprololin PatientswithEssentialHypertension ClinicalStudyGroup Abstract Objective Toevaluatetheefficacyandsafetymeotprololofbisoprololinpatientswithmildtomoderateessential hypertensionandcomparewiththeeffectof metoprolo1． M ethods Patinetswererand~nlyassignedot receivemetoprolol groupO1bispraidgroup(it／=115)。2．5nagot7．5mg／d。ormetoprololgroup(it／=105)50nagot 150mg／dfor6～8wks． Bothgroupswereaddde hydrochlorothiazidealongwithbisopmlolormetoprololtreatmnet． Results Theaveragesystolic bloodpressure(SBP)。average~ tolicbloxlpressure(DBP)nadaverageheartrate(HR)decreasedsignificantlyinboht groupsaftre2week(P0．01、，sbefore)；BPnadHRdecreasedcontinuouslynadsmoothlyduringhteentiretreatmentperi— od：thedecreasedBPmagnitudeinbisopmlolgroup is11．0／8．6mmHg~21．6／16．2mmHg。inmeotpmlolgroup is11．0／ 8．8mmHg~16．7／14．9mmHg；thedecreasedHRvalueinbisopmlolgroupis5．1～8．9beat／min。thatofmetoprololgroup is4．8～7．3beat／min． eresultof bisoprololgroupisbettre thanmetoprololgroup indecreasing Paftre 8weeks’ treamtent(P0．01)． ThetotalefficacyrateforBPdecreaseaftre6weekstreamtnetofbisopmlolgroupis84．3％。that ofrnotoprololgroupis79％(P0．05)；thetotalefficacyrateaftre8weekstreamtnetofbisoprololgroupsi91．3％。thatof metopmlolgroupis81％(PO．Ol1． Ambulatorybloodpressuremonitoring(ABPMlshowsabettre efficacyofbisoprolo thanmetoprololinthedecreasingofnight P(P0．01)-T／PratioisInorethan50％． C -cl璐i伽 B~oprololisasafe。 effective。highlyselective融receptorblocker。longactingnati—hypertensiondrug． Bisop~lolhasagoodtolerance。thead— versereactionsislight． Theefficacyrateisincreaseswithcombinde hydrochlorothiagide． Keywords： hypertension； bisoprolol； metoprolol