比索洛尔对原发性高血压患者左室肥厚逆转效应_张博.pdfVIP

DOI ：10.13191/j.chj.2009.06.88.zhangb.026 # 8 8# ( Chin H eart J) 2009, 21( 6) # # 张 博 (, 121000) : : 40 , 24, ; ( LVST), ( LVPWT) , ( LVEDD), ( LVM I) Ó( PCÓ ), ( IGF-I) , -A ( TNF-A): , (P 0101): , IGF-ITNF-A : 高血压, 原发性; 比索洛尔; 左室重构 : R544. 1 : A : 1009-72 6( 2009) 06-8 8-0 Effect ofbisoprololon left ventricular hypertrophy ZHANG B o ( Department of Cardiology, Jinzhou CentralHospital, Jinzhou 121000, Liaon ing, Ch ina) Abstract AIM: To observe the effect of bisoprolol on left ventricular hypertrophy. METHODS: Forty patientsw ith essential hypertension and left ventricular hypertrophy ( LVH ) w ere treated w ith bisoprolol ( 215 - 10 mg /day) for 24 w eeks. Blood pressu re, left ventricle diastolic dmi ension ( LVEDD), inter- ventricu lar septum thickness ( LVST ), left ventricle mass index ( LVM I), left ventricle posterior w all th ickness ( LVPWT), procollagen type III ( PCIII), insulin-like grow th factor-I ( IGF-I), and tumor necrosis factor-A (TNF-A) w eremeasured before and after treatment. RESULTS: A fterb isoprolol treat- ment, blood p ressure and LVM I, LVPWT, LVST and LVEDD levels significantly decreased (P 0101). In add ition, PCIII, IGF-I and TNF-A levels also significantly decreased (P 0101). CO CLUSIO : Bisoprolol low ers hypertension and reverses LVH. The protective mechanism may be related to its ab ility to reduce IGF-I and TNF-A. Key words: hypertension; b isoprolol; ventricular remodeling ( EH ) 1 , ( LVH) EH 1. 1 对象 2006 6~ 2007 6 , LVH 40: ¹ 1999 , LVH EH WHO /ISH ÑÒ ,