FRAX论文投稿样本.docxVIP

骨折风险评估工具（FRAX?）在评价绝经后女性骨密度变化中的作用蔡舒婷 孙雯 刘红*广西医科大学第一附属医院老年病学内分泌代谢科，南宁 530021摘要：目的探讨骨折风险评估工具（FRAX?）在评价绝经后女性骨密度变化中的作用。材料方法2014年12月-2015年12月于广西医科大学一附院门诊、病房及体检并完成双能X线骨密度测定的绝经后女性166例，问卷采集信息，应用FRAX?中国模式计算代入或不代入股骨颈骨密度时各研究对象10年内骨质疏松性骨折的概率，并结合骨密度测定结果、OSTA及IOF一分钟测试题进行统计学分析。结果（1）骨量异常组年龄较高、体重较轻、BMI较低、身高变化较多、绝经年限较长，两组间具有既往骨折史的人数差异有统计学意义。（2）有或无BMD时，骨量异常组10年内骨质疏松性骨折概率均显著高于骨量正常组。（3）有或无股骨颈BMD时，FRAX?预测值与股骨颈骨密度T值之间均呈显著负相关，而有和无股骨颈BMD的FRAX?预测值之间呈显著正相关。（4）随着年龄或骨质疏松风险的增长，骨量异常发生率逐渐上升，10年内骨质疏松性骨折概率显著升高。（5）10年内主要骨质疏松性骨折概率识别骨量异常的ROC曲线的AUC为0.705（P＜0.001），准确度为中等；10年内髋骨骨折概率识别骨量异常的ROC曲线的AUC为0.743（P＜0.001），准确度中等。结论FRAX?能够反映机体骨密度变化，全面评估骨折风险，并可作为一项基本的筛检工具，应用于识别绝经后女性骨质疏松的高危人群。关键词：骨质疏松性骨折，骨质疏松，骨折风险评估工具，骨密度，绝经后女性Effect ofFRAX? on evaluating the change of bone mineral density in postmenopausal womenCAI Shuting, Sun Wen, LIU HongGeriatric Endocrine Department, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaCorresponding author: LIU Hong, Email: hongmm1@Abstract: ObjectiveThis study aims to investigate the effect of WHO Fracture Risk Assessment Tool (FRAX?) on reflecting the change of bone mineral density in postmenopausal women.Methods166 postmenopausal women were recruited including outpatients, hospitalized patients and people who underwent health assessment in the First Affiliated Hospital of Guangxi Medical University. Bone mineral density was measured by dual energy x-ray absorptiometry．All risk factors were collected from subjects requested in the FRAX? assessment. Each individual 10-year probability of major fracture and hip fracture were calculated by the FRAX?algorithmsof Chinese model (with and without BMD). The statistical analysis was performed with a SPSS software．ResultsThe patients with abnormal bone mass (osteopenia or osteoporosis) had elder age, light weight, lower BMI,more reduction in height,longer menopause durationcompared with the normal group. Except for history of fragility of fracture, other clinical risk factors were not significant between t