舒郁颗粒干预缺血性卒中后抑郁的临床观察.pdfVIP

摘要 摘 要 目的：观察舒郁颗粒对缺血性卒中后抑郁的临床疗效，进一步探讨其作用 机理。 方法 ：将 80 例缺血性卒中后抑郁患者随机分为两组，治疗组给予舒郁颗粒 （源于河南中医学院第一附属医院张怀亮教授的经验方）治疗，每次 1 剂，200ml 水冲服，每日 2 次，4 周为一疗程，合计 2 个疗程。对照 组给予解郁丸治疗，每次 1 包，每 3 次， 4 周为一疗程，总计 2 个疗 程。两组在治疗期间根据病情需要给予相应的基础治疗。观察病人治 疗前、治疗 4 周、8 周汉密尔顿抑郁量表评分（HAMD ）、Zung 抑郁自 评量表评分（SDS ）、日常生活能力量表评分（ADL ）、神经功能缺损 量表评分（SSS ）及中医症状积分的变化。 结果 ：①治疗 8 周后两组病人上述各指标均有显著性差异（P0.05）,②治 疗 8 周后治疗组与对照组比较有显著性差异（P0.05 ）。 结论 ：舒郁颗粒能显著改善缺血性卒中后抑郁症的临床表现，并促进神经 活动功能的恢复。 关键词 ：缺血性卒中后抑郁 舒郁颗粒 解郁丸 - 1 - 舒郁颗粒干预缺血性卒中后抑郁的临床观察 Shu-Yu-Ke-Li Interfere with Ischemic Post-Stroke Depression in Clinical Research SUN Zhixia (Clinic of Integrated Traditional Chinese and Western Medicine) Directed by Zhang Huailiang ABSTRACT OBJECTIVE : To observe the clinical therapeutic effect of Shu-Yu-Ke-Li on the ischemic post-stroke depression, and further study its mechanism function. METHODS : 80 cases of depression after ischemic stroke patients were randomly divided into two groups: during eight weeks of basic therapy, one group were treated with SYKL (one dose, bid), the other were treated with Jie-Yu-Wan (a packet, qd ). Patients were evaluated by use of the HAMD, SDS, ADL, SSS and symptom integral. Statistical analysis was performed by using an intent-to-treat approach comparing the two group at day 0 (baseline) and weeks 4 and 8 (end point). RESULTS : ① There were significant differences in HAMD, SDS, ADL, SSS and symptom integral for the groups before and after treatment at end point (P0.05). ② There were significant differences in mean HAMD, SDS, ADL, SSS, and symptom