高龄患者应用抗菌药物处方分析.pdfVIP

中国药物应用与监测 2014 年12月第11卷第6 期 Chinese Journal of Drug Application and Monitoring, Vol.11, No.6, December 2014 高龄患者应用抗菌药物处方分析 1 1,2（1.上海市闵行区古美社区卫生服务中心药剂科，上海 201102 ；2. 上海市闵行区卫生和计划生育委员会，上海 201199 ） 陈家仪 ，杨耀芳 [摘要]　目的：通过评价抗菌药物用药现状，为高龄患者合理用药提供参考。方法：采用回顾性分析方法，收集2013 年 1 – 12 月 门诊高龄患者抗菌药物处方，共计1514 张，利用用药频度（DDDs ）和药物利用指数（DUI ）分析法，对用药情况进行统计分 析。结果：我中心使用的 20 种抗菌药物的 DUI 在 0.32 ~ 1.42 之间；DDDs 排名前 3 位分别是头孢菌素类、喹诺酮类和大环内 酯类，药品品种依次是头孢呋辛酯、左氧氟沙星（口服制剂）和头孢呋辛钠（注射制剂）。女性患者抗菌药物使用量所占比例 （64.07 ％）高于男性，患者年龄主要分布在91 ~ 95 岁之间。结论：我中心高龄患者门诊抗菌药物应用基本合理，但仍存在抗 菌药物注射剂型使用比例偏高、用药剂量偏大等情况，应加强临床监管。 [关键词]　抗菌药物；高龄患者；用药频度；药物利用指数；处方分析 [ 中图分类号]　R969.3　　 [ 文献标识码]　A　 [ 文章编号]　1672 – 8157(2014)06 – 0380 – 04 Prescription analysis on the use of antibacterials in elderly patients 1 1,2(1. Department of Pharmacy, Gumei Community Health Center, Shanghai 201102, China; 2. Minhang CHEN Jia-yi , YANG Yao-fang District Commission of Health and Family Planning, Shanghai 201199, China) [ABSTRACT]　Objective: To provide the evidence on rational use of drugs for elderly patients by evaluating the utilization of antibacterial agents. Methods: A total of 1514 antibacterial outpatient prescriptions of elderly patients were collected from January to December in 2013 of our center. The varieties of antibacterials were analyzed by DDDs and drug utilization index (DUI). Results: The DUI of 20 kinds of antibacterials used in outpatient were in the range of 0.32 – 1.42. The top 3 antibacterials in terms of DDDs were cephalosporins, quinolones and macrolides, and the drugs were cefuroxime axetil, levofloxacin (oral preparation) and cefuroxime sodium injection preparation). The usage proportion in female patients was higher than that of male patients, accounting ( for 64.07%, the age of the patients was mainly 91 – 95 years. Conclusion: The application of antibacterials was basically rational for elderly patients in our center, b