5例结外Rosai—Dorfman病临床病理学观察.docVIP

5例结外Rosai—Dorfman病临床病理学观察 　　[摘要] 目的 探究结外Rosai-Dorfman病临床病理学特征。 方法 选取2007年1月～2012年7月长兴县人民医院收治的5例结外Rosai-Dorfman病患者作为研究对象，观察其临床特点，并将其病变组织进行HE和免疫组织化学染色观察病理结构。 结果 HE染色中病理组织主要表现为皮肤真皮层出现淋巴结中扩张的血窦样结构，由交替性分布的淡染带和深染带组成；免疫组织化学染色主要表现为组织细胞均弥漫强阳性表达S-100蛋白。 结论 结外 Rosai-Dorfman病有其特定的病理学特征，组织学上应与慢性炎性病变、纤维组织细胞肿瘤、朗格汉斯细胞组织细胞增生症、炎性假瘤、鼻硬结病等病进行鉴别诊断。 　　[关键词] 结外Rosai-Dorfman病；病理观察；免疫组化；诊断 　　[中图分类号] R551.1 [文献标识码] A [文章编号] 1673-7210（2013）11（c）-0111-03 　　Clinicopathological observation of 5 cases patients with extranodal Rosai-Dorfman disease 　　DENG Xiaoe1 LI Liqin2 　　1.Department of Pathology， the Peoples Hospital of Changxing County in Huzhou City， Zhejiang Province， Changxi 313100， China； 2.Central Laboratory， Huzhou Central Hospital of Zhejiang Province， Zhejiang Province， Huzhou 313000， China 　　[Abstract] Objective To explore clinical pathological characteristics of extranodal Rosai-Dorfman disease. Methods The clinical features of 5 patients with Rosai-Dorfman from January 2007 to July 2012 in the peoples Hospital of Changxing County were observed， pathogeny structure of diseased tissues were observed through the HE and immunohistochemica method. Results Expansion blood sinus structure in lymph was presented in the dermis composed of alternating distribution of light bands and dark bands in HE staining observation and tissue cells were mainly manifested as diffuse strong positive expression of S-100 protein in immunohistochemical observation. Conclusion Extranodal Rosai-Dorfman disease has the characteristics of its specific pathology and should be differential diagnosis with chronic inflammatory lesions， fibrous tissue tumor cell， Langerhans cell histiocytosis， inflammatory pseudotumor， and nasal scleroma disease in histology. 　　[Key words] Extranodal Rosai-Dorfman disease； Pathological observation； Immunohistochemistry； Diagnosis 　　Rosai-Dorfman病（Rosai-Dorfman disease，RDD）又称为窦组织细胞增生症伴有大块淋巴结肿大（sinus histiocytosis with Massive Lymphadenophy ，SHML），本病于1961年由Lennert首先报道，1969