从支气管哮喘、荨麻疹患者外周分泌物中分泌性免疫球蛋白A论“肺主皮毛”.docVIP

从支气管哮喘、荨麻疹患者外周分泌物中分泌性免疫球蛋白A论“肺主皮毛” 　　摘要：目的 通过测定支气管哮喘及慢性荨麻疹患者唾液、痰液、鼻分泌液中分泌性免疫球蛋白A（SIgA），寻求发病过程中外周分泌物中SIgA的变化规律，探讨肺病与皮病的关联性，为“肺主皮毛”理论进一步提供依据。方法 收集单纯支气管哮喘患者32例（哮喘组），支气管哮喘合并慢性荨麻疹患者33例（合并组），单纯慢性荨麻疹患者31例（荨麻疹组），以及正常人30例（正常组），采用ELISA法对其痰、唾液及鼻分泌液中的SIgA进行检测。结果 3个疾病组唾液、鼻腔分泌液中SIgA含量均较正常组明显升高（P0.05）；唾液中SIgA含量荨麻疹组较合并组升高（P0.01）；哮喘组、合并组痰液中SIgA含量均较正常组、荨麻疹组降低（P0.01）；除正常组唾液和痰液中SIgA含量呈负相关（r=-0.369，P=0.045）外，其余3组各分泌物样本中SIgA的分布无相关性。结论 SIgA在支气管哮喘和慢性荨麻疹患者中有共同表达，“肺主皮毛”理论在支气管哮喘和慢性荨麻疹的发病中主要体现在病理方面，而黏膜免疫相关介质可能是二者之间联系的物质基础。 　　关键词：支气管哮喘；慢性荨麻疹；分泌性免疫球蛋白A；肺主皮毛 　　DOI：10.3969/j.issn.1005-5304.2012.12.006 　　中图分类号：R259.622.5；R275.082.4 文献标识码：A 文章编号：1005-5304（2012）12-0013-03 　　Discussion on the Theory of “Lung Govering Skin and Hair” from the Angle of SIgA in Secretions of Asthma and Urticaria Patients ZHANG Yan-li， WANG Na-na， LI Feng-sen （TCM Hospital Affiliated to Xinjiang Medical University， National TCM Clinical Research Bases in Xinjiang， Urumqi 830000， China） 　　Abstract：Objective To seek the common pathological embodiment and rules of mucosal immunity changes in the disease course of bronchial asthma and chronic urticaria， and discuss the relevancy between pulmonary diseases and dermatosis through determining secretory immunoglobulin-A （SIgA） in saliva， sputum and nasal secretions， thereby further discuss the scientific connotation of “lung governing skin and hair” theory. Methods Thirty-two patients with pure bronchial asthma （asthma group）， 33 patients with bronchial asthma combined with chronic urticaria （combined group）， 31 patients with chronic urticaria （urticaria group） and 30 normal people （normal group） were collected， ELISA method was adopted to test SIgA in their sputum， saliva and nasal secretions. Results The SIgA contents in saliva and nasal secretions were higher in asthma group， urticaria group and combined group compared with control group （P0.05）. SIgA in saliva secretion was higher in uriticaria group compared with combined group （P 　　Key words：bronchial asthma；chron