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富亮氨酸胶质瘤失活1蛋白抗体脑炎临床特点及诊治体会 李红芳 吕占云* 齐子友 郝永楠 张爱梅 济宁医学院附属医院神经内科,山东，272029 摘要：目的 探讨富亮氨酸胶质瘤失活1蛋白 leucine-rich gliomainactivated-1，LGI1 抗体阳性边缘叶脑炎临床特点、诊断、治疗及预后。方法 对近期收治的1例LGI1抗体脑炎患者的临床症状、影像学检查结果及诊治过程进行总结性回顾，进而对的诊治过程进行分析与探讨。结果 男性患者表现为精神行为异常及癫痫发作，抗癫痫药物抵抗，提示双侧颞叶内侧异常信号，血和脑脊液检测显示LGI1抗体阳性。经激素冲击治疗，效果良好，后联合静注丙种球蛋白，达到临床痊愈。结论 LGI1抗体脑炎是一种具有独特临床表现的自身免疫性疾病，通过血清学检测可明确诊断，对患者早期诊断并及时开展免疫干预治疗，能够达到良好的预后。 关键词：富亮氨酸胶质瘤失活1蛋白；边缘叶脑炎；免疫疗法 The Clinical Characteristics and Experience of diagnosis and treatment of Leucine-rich Gliomainactivated-1 Antibody encephalitis LI Hong-fang, LV Zhan-yun ,QI Zi-you, HAO Yong-nan.,ZHANG Ai-mei Department of Neurology, Affiliated Hospital of JiNing Medical College, Shandong 272029,China Abstract：Objective To analysis the clinical characteristics, diagnosis, treatment and prognosis of?leucine-rich?glioma?inactivated-1 LGI1 ?-antibody?associated?limbic?encephalitis LE . Method From a summative review of the clinical symptoms, imaging findings and treatment process of one?case?with?LGIl-antibody?associated?LE, in order to analysis and discuss the whole process of diagnosis and treatment. Conclusion Male patients on admission to mental behavior and seizures, antiepileptic drug resistance. The imaging prompts the anteromedial temporal lobes inside abnormal signal, blood and cerebrospinal fluid examination showed LGI1 antibody was positive. The effect is good for the patient from the hormone shock therapy,after joint Intravenous immune globulin, achieve clinical recovery. Results LGI1 antibody encephalitis is a autoimmune diseases with unique clinical manifestations, by serological testing can confirm the diagnosis of the disease. Patients with early diagnosis and timely immunization intervention, not only can effectively cure the patient, and the patient is able to achieve a good prognosis. Key words：LGI1；LE；Immunotherapy 边缘脑炎（limbic encephalitis，LE）是一种累及大脑边缘性结构（海马、杏仁核、岛叶、扣带回皮质）的中枢神经系统炎性疾病，最早由Corsellis于1968年进行报道。早期临床发现LE患者多伴有小细胞肺癌、胸腺瘤、淋巴瘤等恶性肿瘤，因此认为LE的发生与肿瘤相关，