miR-128 and its target genes in tumorigenesis and metastasis》.pdfVIP

E X P E R I M E N T A L C E L L R E S E A R C H 3 1 9 ( 2 0 1 3 ) 3 0 5 9 – 3 0 6 4 Available online at journal homepage: /locate/yexcr Review Article miR-128 and its target genes in tumorigenesis and metastasis a,n b a a c c,nn Molin Li , Weiming Fu , Lulu Wo , Xiaohong Shu , Fang Liu , Chuangang Li aDalian Medical University, Dalian 116044, China bCenter for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458, China cThe second affi liated hospital of Dalian Medical University, Dalian 116023, China a r t i c l e i n f o r m a t i o n a b s t r a c t Article Chronology: MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18–24 nucleotide length single- Received 10 April 2013 strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies Accepted 27 July 2013 have shown that miR-128 enriched in the brain plays an important role in the development of Available online 16 August 2013 nervous system and the maintenance of normal physical functions. Aberrant expression of Keywords: miR-128 has been detected in many types of human tumors and its validated target genes are MicroRNA-128 (miR-128) involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. Target genes