Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability》.pdfVIP

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Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability》.pdf

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Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability》.pdf

Biochemical and Biophysical Research Communications 430 (2013) 975–980 Contents lists available at SciVerse ScienceDirect Biochemical and Biophysical Research Communications journal homepage: www.else /locate/ybbrc Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability Vinod K. Mishra a,⇑, Mayakonda N. Palgunachari a, David T. McPherson b, Gattadahalli M. Anantharamaiah a,c,1 a The Atherosclerosis Research Unit, Department of Medicine, UAB Medical Center, Birmingham, AL 35294, USA b Center for AIDS Research, UAB Medical Center, Birmingham, AL 35294, USA c Department of Biochemistry and Molecular Genetics and Comprehensive Cancer Center, UAB Medical Center, Birmingham, AL 35294, USA a r t i c l e i n f o a b s t r a c t Article history: High density lipoprotein (HDL) associated paraoxonase-1 (PON1) is crucial for the anti-oxidant, Received 21 November 2012 anti-inﬂammatory, and anti-atherogenic properties of HDL. Discoidal apolipoprotein (apo)A-I:1-palmi- Available online 19 December 2012 toyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) complex has been shown to be the most effective in binding PON1, stabilizing it, and enhancing its lactonase and inhibitory activity of low density lipoprotein Keywords: oxidation. Based on our earlier study demonstrating that apoA-I mimetic peptide 4F forms discoidal High density lipoprotein complex with 1,2-dimyristoyl-sn-glycero-3-phosphocholine, we hypothes