中国湖北汉族重症肌无力与HLA-Ⅱ类等位基因的关联.pdfVIP

中国病理生杂志/990702 中国病理生理杂志 CHINESE JOURNAL OF PATHOPHYSIOLOGY 1999年 第15卷　第7期 Vol.15　No.7 1999 中国湖北汉族重症肌无力 与HLA-Ⅱ类等位基因的关联 龚非力　杨志章 　熊平　徐金枝　徐勇　姜晓丹　吴雄文 S.Ferencik　Yanj un Liu　H.Grosse-Wilde 　　摘　要　目的和方法：探讨中国湖北汉族重症肌无力(MG) 患者与HLA-Ⅱ类等位 基因的关联。利用PCR/SSP和PCR-RFLP技术对湖北地区91例MG患者进行 HLA-Ⅱ类 (HLA-DRB1、DQB1和DPB1)基因型别分析，并与168例正常个体比较。 结果：患者组 (1)：HLA-DRB1*0901、DQB1*0303和DPB1*0501等位基因频 率明显高于对照组，RR值 分别为4.12、3.04和3.01，P＜0.01；(2)HLA-DPB1*0202 等位基因频率明显低于对照组， RR值为0.13，P＜0.05。结论：中国 湖北汉族群体中MG与HLA-DRB1*0202、等位基因 正关联，而与HLA-DPB1*0202等位基因呈 负关联，与白种人群相比，这种关联对中国 湖北汉族MG病人来说是特有的。 　　主题词　重症肌无力； HLA抗原；基因表达 Association of HLA class Ⅱ (DRB1/DQB1/DPB1) alleles and myasthenia gravies in the Han nationality of Hubei province GONG Fei-Li, YANG Zhi-Zhang, XIONG Ping, XU Jing-Zhi, XU Yong, JIANG Xiao-Dan, WU Xiong-Wen Department of Immunology, Tongji Medical University, Wuhan(430030) S.Ferencik, Yanjun Liu, H. Grosse-Wilde Institute of Immunology, Essen University, Germany 　　Abstract ：AIM ：To investigate the association of polymorphism o f HLA class Ⅱ genes (DRB1/DQB1/DPB1) with myasthenia gravies(MG). METHODS ：HLA class Ⅱ alleles of 91 patients with MG and that of 168 normal individuals of Han nationality of Hubei province were typed by using PC R/SSP and PCR/RFLP.RESULTS ：(1) Gene frequencies of HLA-DRB1*090 1(RR=4.12, P＜0.01), HLA-DQB1 •0303(RR=3.04,P＜ 0.01) and DPB1*0501(RR =1.22,P＜0.01) are much higher in MG patients than in normal controls; (2) Gene frequencies of HLA-DPB1*0202(RR=0.12,P＜0.05) are much lower in MG pa tients than in normal controls. CONCLUSION ：There is a positive co rrelation between HLA-DRB1*0901、DQB1*0303、DPB1*0501 and MG. There is a nega tive correlation between HLA-DPB1*0202 and