血清AFP-L3、GP73检测联合CT扫描在肝细胞癌诊断中的价值.pdfVIP

现代肿瘤医学 2015年 01月 第 23卷第 1期 MODERNONCOLOGY，Jan．2015，VOL．23，NO．O1 ．101． 血清AFP—L3、GP73检测联合 cT扫描在肝细胞癌诊断中的价值 贾红莲 ，黄彩云 ，宋君利 ，李世龙。，周秀艳 ，王晓蕊。 DiagnosticvalueofserumAFP—L3，GP73andCTscanparalleluseindiagnosisofhep— atocellularcarcinoma JiaHonglian ，HuangCaiyun ，SongJunli，LiShilong，ZhouXiuyan ，WangXiaorui L‘etingCountyHospital，HebeiTangshan063699，China； ePeople HospitalofTangshan，HebeiTangshan063000，China；Hebei TangshanXieheHospital，HebeiTangshan063000，China． A【bstract】 Objective：ToexplorethevalueofdetectingtheserumAFP—L3，GP73level，CTscanningandparallel usethetwokindsoftechnologiesintheearlydiagnosisofhepatocellularcarcinoma(HCC)．Methods：TouseELISA methodtotesttheseFum AFP—L3andGP73levels，ROC curvetodeterminethecut—offleveltodiagnoseHCC．To analyze164lesionsof141patientswithliverdiseaseslesionsbyCTscanandthreedimensionalreconstructionima— ges．ToexplorethevalueofparalleluseAFP—L3，GP73andCTscaninHCCdiagnosis．Results：Theaveragelevelof AFP—L3inthepatientswithHCCwas(113．58±63．62)ng／mlsignificantlyhigherthanthosethepatientswithbe— nignliverdiseases[(23．19±34．54)ng／ml，P0．001]．TakingAFP—L3level≥38．47ng／mlasdiagnosticcrite— ria．thesensitivityofAFP—L3levelinHCC diagnosiswas81．08％ andthespecificitywas88．06％ ，theaccuracy was87．23％．TheaveragelevelofGP73inthepatientswithHCCwas(126．55．4-49．56)ng／mlsignificantlyhigher thanthosethepatientswithbenignliverdiseases[(56．97±26．48)ng／ml，P0．001]．TakingGP73level≥ 69．44ng／mlasdiagnosticcriteria，thesensitivityofGP73levelinHCCdiagnosiswas75．68％ andthespecificitywas 91．04％ ，theaccuracywas88．65％ ．UseCT scan inHCC diagnosis，thesensitivitywas82．43％ ，thespecificitywas 91．04％ ，theaccuracywas90．07％．ParallelseYllm AFP—L3，GP73levelandCTscanimagesinHCCdiagnosis，the sensitivitywas85．14％ ，specificitywas92．53％ ，accuracywas92．19％ ．Conclusion：Thediagnosticsensitivity，spe— cificitvandaccuracy