孕妇血浆纤维蛋白原D_二聚体含量测定和临床意义_万波.pdfVIP

2004 2 20 2 # 97 # : 1005- 2216( 2004) 02- 0097- 02 D- 1) 2) 3) 1) 1) 3) 2) 2) 万 波 王冬娥 鞠文东 白宝敏 江 陵 霍 山 邓坤仪 李栓文 = 探讨孕妇血高凝状态相关 子纤维蛋白原(Fib) D-二聚体含量的变化及发生弥漫性血管内凝 血( DIC) 高危风险可能阈值范围 2001 年12 月至2003 年3 月采用免疫散射比浊法和Clauss 法分别检测 孕妇组2672 例孕妇和对照组204 例非孕妇女的D-二聚体和Fib 水平, 并对孕妇组中2019 例晚期孕妇进行 DIC 追踪研究 孕妇组的D-二聚体Fib 明显高于对照组, 其中D-二聚体和Fib 随着妊娠时间的延长而逐渐升 高早中晚孕各组相比( P 0101) ; 晚期孕妇中共6例发生 DIC, 19 例 D-二聚体和Fib 都分别高于 5mg/ L 和 5g/ L, 有4 例发生DIC, 2 例D-二聚体 5mg/ L, Fib 115g/ L; 2 例Fib 5g/ L, D-二聚体 015mg/ L, 各发生DIC 1 例 D-二聚体 5mg/ L 和Fib 5g/ L 同时存在, 或者两 个指标明显失衡呈分离状态, 可作为孕妇发生 DIC 高危阈值, 两 个指标相结合可更有效预测 DIC 的发生 = 纤维蛋白原 D-二聚体 弥漫性血管内凝血 : R71 : A Clinical significance of plasma level changes of D- dimer and fibrinogen in pregnant women. * Wan Bo , Wang * Dong. e, Ju Wendong , et al . Zhongshan B o. ai H osp ital , Zhongshan 528403, China Abstract Obj ective To explore the changes of plasma levels of Fib and D-dimers and explore the risk range of DIC and thrombosis in pregnant w omen.Methods Plasma levels of D-dimers and Fib were measured by means of immuno- turbidimetric method and Clauss method.Results The plasma levels of D-dimer and Fib of pregnant women were high- er t han t hose of nonpregnant women( P 01 01) . The levels of D-dimer and Fib increased w ith the progress of pregnan- cy. There were 6 cases who developed DIC in late-term pregnancy and 19 cases w hose D-dimer and Fib levels w ere more than 5mg/ L and 5g/ L;4 cases developed DIC in these 19 cases; 2 cases w ere w ith D-dim