两种剂量辛伐他汀治疗急性冠脉综合征的临床疗效评价.pdfVIP

两种剂量辛伐他汀治疗急性冠脉综合征的临床 疗效评价 冯姗，李颢(河南省汝南县人民医院心内科，汝南县463300) 中图分类号R972+．6文献标识码A 文章编号 1672—2124(2005)03—0146—03 摘要 0．05)。结论：短期辛伐他汀强化治疗，可明显减少炎症反应，稳定斑决，改善血管内皮功能。 关键词 辛伐他汀；冠状动脉病；降脂药，高敏c反应蛋白；白细胞介素一6；假性血友病因子 EvaluationoftheClinicalEffectofTwoDifferent SimvastatinonAcute of Coronary Dosage FENG of ofHenan Shan，LI Hao(DepartmentCardiology，RunanPeople’SHospital 463300) the ABSTRACTOBJECTIVE：Toeffectoftwodifferentof andlow study dosagesimvastatin(1argedosage，40mg／ddosage， forone and in withacute week)onhs—CRP，IL一6，vWF 20mg／d lipidspatients coronary 69 withACSwere dividedintothree A(23 B(23cases)andC(23 patients randomly groups：groupcases)，group group were and simvastatinforoneweekwithout cases)．Theyrespectivelygiven20mg／d 40mg／d lipid—lowering levelsof and ineach before treatment levels hs—CRP，IL一6，vWF andafter were of lipid group hs—CRP．IL一6andvWF in C in A B decreased thanthose and afteroneweek’streatment significantly group group group (P0．05)．Thelevelsof andLDL—Chadno inthree after TC，TG，HDL—C change groups CONCLUSION：Forthe with simvastatininashort can decrease patientsACS，using40mg／d periodobviously the and bloodvesselendotheliumfunction． reaction，stabilize plaqueimprove KEYWORDS sensitiveC—reactive si