摘要：目的：探讨喷他佐辛复合丙泊酚用于无痛人流手术的最佳.docVIP

不同剂量喷他佐辛联合丙泊酚用于无痛人流手术的临床研究 邱林（郑州大学第三附属医院麻醉科，郑州 450052） 摘要：目的 探讨喷他佐辛复合丙泊酚用于无痛人流手术的最佳麻醉剂量。方法选择人工流产患者200例，ASA I ～Ⅱ级，随机分为4组，每组50例。观察组分为Ⅰ、Ⅱ、Ⅲ组，分别为喷他佐辛0.2mg/kg、0.4mg/kg、0.6mg/kg复合丙泊酚用于人工流产手术麻醉；对照组（C组）为单纯应用丙泊酚用于人工流产手术麻醉。观察麻醉效果，记录丙泊酚的总剂量、意识恢复及药物不良反应。结果 Ⅱ组和Ⅲ组镇痛效果显著优于C组（P0.05）；意识消失时间在各组间无明显差异，Ⅱ组和Ⅲ组意识恢复时间明显短于C组（P0.05），丙泊酚总用量与C组相比明显减少（P0.05）；Ⅲ组不良反应明显增加。结论 适当剂量的喷他佐辛（0.4mg/kg）联合丙泊酚用于无痛人流手术安全、有效、不良反应少。 关键词: 喷他佐辛；丙泊酚；无痛人流 Clinical study the efficacy of different dosage of pentazocine combined with propofol in general anaesthesia for painless artificial abortion QIU Lin (The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) Abstract: Object To investigate the optimum dose of pentazocine combined with porpofol on painless artificial abortion. Methods 200 ASA I一Ⅱpregnant women undergoing painless abortion were randomly divided into four groups (n=50)：group Ⅰ，Ⅱand Ⅲaccepted injection of propofol combined with pentazocine at the dosage of 0.2mg/kg, 0.4mg/kg, 0.6mg/kg respectively and group C only accepted propofo1. Anaesthetic effect was observed. Total dosage of propofol, recovery time and side effect were recorded. Results Analgesia effect in group Ⅱ and Ⅲ was superior to group C （P0.05）. There was no statistical significance in every group on the time of consciousness loss. The recovery time in group Ⅱ and Ⅲ was significantly shorter than group C （P0.05）. The total dosage of propofol in group Ⅱ and Ⅲ was obviously lessen than group C （P0.05）. Compared to the groupⅠ，Ⅱ and C, the side effects was significantly increased in group Ⅲ. Conclusion The proper dose of pentazocine (0.4mg/kg) combined with propofol on painless artificial abortion was safe, effective and less side effects. Key words: Pentazocine, Propofol, Painless artificial abortion 近年来，丙泊酚被广泛用于无痛人流手术，由于该药镇静充分而镇痛不足，术中疼痛刺激致使部分患者肢体扭动、呻吟、多汗，增加手术风险，基于此，有关丙泊酚联合镇痛药物的配伍方案不断被提出，并不断该进，亦有关于喷他佐辛联合丙泊酚用于无痛人流的报道[1]，但就喷他佐辛适宜剂量的研究目前鲜有报道，本研究旨在通过对不同剂量喷他佐辛联合丙泊酚应用的临床观察，寻找适宜的喷他佐辛联合用药剂量，为该药在无痛人流手术静脉麻醉中的临床应用提供参