牛磺酸对大鼠精氨酸加压素及学习记忆行为的作用.pdfVIP

中国行为医学科学 1996 年第 5 卷第 4 期 1·85 · 牛磺酸对大鼠精氨酸加压素及学习记忆行为的作用 李太志　顾雪英 ( 目的　观察牛磺酸对大鼠精氨酸加压素和学习记忆行为的作用。方法　以推挽灌流法对大鼠下丘脑室旁核灌流不同浓度 0. ) 04、0. 4、4 牛磺酸, 用放射免疫法测定其挽出液内精氨酸加压素的含量; 再用跳台法观察动物学习记忆行为的变化。结果　 mmo l l 0. 04 牛磺酸组挽出液内加压素含量增加, 动物学习成绩提高; 0. 4～ 4 组加压素含量降低, 动物记忆能力增强。结论 mmo l l mmo l l 低浓度牛磺酸可促进加压素释放有助于学习; 高浓度则使加压素含量减少, 可能与室旁核储存或合成加压素增多有关, 故有助于 记忆。 　　关键词　牛磺酸　精氨酸加压素　推挽灌流法　学习记忆　下丘脑室旁核 Effects of taur ine on the release of arg in ine vasopressin and learn ing- memory behav iors in rats L i T aiz h i, Gu X uey ing D ep art m ent of P hy siology , X uz hou M ed ical Colleg e, X uz hou , J iang su 221002, Ch ina objec ive To study the effects of taurine on the release of arginine vasop ressin (AV P ) and the learning and m emo ry behavio rs in rats. M ethods T he paraventricular nucleus (PVN ) in the hypo thelam us of rats w as perfused w ith taurine of varied concentrations (0. 04 , 0. 4 4. 0 ) - . - mmo l L mmo l L and mmo l L by m eans of push pull perfusion T he AV P content in pull out fluid w as deter m ined by AV P radio imm unoassay (AV P - R IA ). T he learning and m emo ry behavio rs of the rat w ere evaluated by step - dow n . - 0. 04 test Results T he AV P content in pull out fluid w as increased fo llow ing mmo l L taurine perfusion and the learning sco re of . 0. 4～ 4. 0 , the anim al w as increased Fo llow ing the perfusion w ith mmo l L taurine the AV P content w as decreased a