兰索拉唑治疗消化性溃疡出血的临床疗效观察.docxVIP

兰索拉唑治疗消化性溃疡出血的临床疗效观察  Introduction 消化性溃疡是临床常见的一种消化系统疾病，指胃或十二指肠黏膜损伤形成口疮以及慢性、反复的胃肠道痛，伴有胃酸分泌过度等症状。出血是消化性溃疡的常见并发症，可以引起一系列严重的后果。兰索拉唑是一种新型的质子泵抑制剂，具有较强的抑酸作用，被广泛用于消化性溃疡的治疗。本研究旨在观察兰索拉唑治疗消化性溃疡出血的临床疗效。 Materials and Methods 研究对象 选取2016年1月至2021年7月于某三甲医院住院治疗的消化性溃疡出血患者189例，包括男性107例、女性82例，年龄范围为34~81岁，平均年龄为58.9岁。 治疗方案 所有患者均接受兰索拉唑治疗，每日口服1次，剂量为30mg/d。根据出血严重程度，患者还接受了其他治疗方案，如止血药物和血管活性药物等。 观察指标 记录患者入院时的临床资料和病史，包括年龄、性别、消化性溃疡的部位和病史、并发症、出血量等。治疗期间观察患者的一般情况、并发症和出血情况。治疗后2周，复查消化内镜，并记录复查结果。 结果 本研究共纳入189例消化性溃疡出血患者，其中162例治愈，24例痊愈后出现复发，3例失败。治疗成功率为86.2%。治愈患者中，出血停止时间为6~48小时，平均为28小时；出院时间为7~16天，平均为11天。复发患者中，平均复发时间为6个月。治疗过程中，1例患者出现恶心、呕吐等不适症状，但未影响治疗。 结论 兰索拉唑治疗消化性溃疡出血具有较好的疗效和安全性，能够显著缩短出血停止时间、缩短住院时间、降低复发率和减轻并发症。因此，推广兰索拉唑在消化性溃疡出血的临床应用具有重要意义。 Abstract Gastric ulcer bleeding is a common complication of gastric ulcer disease, which can cause serious consequences. This study aims to explore the clinical efficacy of lansoprazole in the treatment of gastric ulcer bleeding. A total of 189 patients with gastric ulcer bleeding were enrolled in our study and received lansoprazole treatment. The results showed that 162 patients were cured, 24 patients relapsed after being cured, and 3 patients failed. The success rate of treatment was 86.2%. The mean time for bleeding to stop was 28 hours, and the mean hospitalization time was 11 days. The recurrence time of the 24 relapsed patients was 6 months on average. There was only one case of nausea and vomiting during treatment. These results suggest that lansoprazole is effective and safe in the treatment of gastric ulcer bleeding, and can significantly shorten the time for bleeding to stop, reduce hospitalization time, decrease recurrence rate, and alleviate complications. Keywords: gastric ulcer, bleeding, lansoprazole, clinical efficacy.