正常血细胞形态 Normal Blood Cell Morphology.ppt

Erythrocyte （红细胞） 6-8 μm in diameter, 7.2 μm on average, biconcave disk, a small area of central pallor, anuclear, pink Erythroid maturation sequence stages of megakaryocytic maturation: megakaryoblast （原始巨核细胞） promegakaryocyte （幼稚巨核细胞） granular megakaryocyte （颗粒型巨核细胞） thrombocytopoietic megakaryocyte(产血小板型巨核细胞) naked megakaryocyte （裸核型巨核细胞） platelet （血小板） Megakaryocyte series Megakaryocytopoiesis development occurs by endomitosis Megakaryoblast （原始巨核细胞） S: 15-30 μm, round or irregular N: large, round or irregular. coarse reticular chromatin in purple, 2-3 vague nucleoli C: small to moderate cytoplasm in deep blue, may have pseudopod, no granules Promegakaryocyte （幼稚巨核细胞） S: 30-50 μm, irregular N: irregular in shape, may show slight lobulation, coarser chromatin, nucleoli indistinct C: more amount cytoplasm in deep blue, reddish-purple granules visible, pseudopod visible Granular megakaryocyte （颗粒型巨核细胞） S: giant, 40-70 μm, integrity membrane N: giant , multiple nuclei or multi-lobulation, coarser patchy chromatin pattern C: very plentiful cytoplasm full of purple granules Thrombopoietic megakaryocyte （产血小板型巨核细胞） S: 40-70 μm, irregular, blurred membrane N: giant, hyperploid nuclei often overlie with clumped chromatin C: very plentiful cytoplasm in reddish, granules cluster and bud off to become platelet P Naked megakaryocyte （裸核型巨核细胞） A mature megakaryocytic nucleus without cytoplasm Platelet 1–4 μm in diameter, giving a star-like appearance, anuclear, light blue cytoplasm with fine reddish blue granules near the center. megakaryocytopoeisis and megakaryocytes megakaryocytes in endomitosis 胞体：大 小 （巨核及早幼粒细胞相反） 核浆比例： 核大浆小 核小浆多 胞核：大小：大 小 核型：圆/椭圆 凹陷 杆状 分叶（RBC无） 核染质：细致疏松 粗糙致密 血细胞发育成熟的一般规律 核仁：多（清晰） 小（模糊） 消失 核膜：不明显 明显 胞浆： 量：少 多（淋巴系不明显） 颜色：深蓝 浅蓝 粉红 颗粒：无 有 原粒 原红 Quiz 1 ① ② ④ ③ ⑤ ⑥ Quiz 2 ① ② ③ ④ Quiz 3 ① ② ③ ④ ⑤ ⑥ ⑦ Quiz 4 ① ② Quiz 5 ① ② Quiz 6 Homework： T