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文献-Hsp90 molecular chaperone inhibitors Are we there yet.docx

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DOI:10.1158/1078-0432.CCR-11-1000 Hsp90?Molecular?Chaperone?Inhibitors:?Are?We?There?Yet? Len?Neckers?and?Paul?Workman Clin?Cancer?Res?2012;18:64-76.?Published?online?January?2,?2012. Updated?Version Cited?Articles Citing?Articles E-mail?alerts Reprints?and Subscriptions Permissions Access?the?most?recent?version?of?this?article?at: doi: HYPERLINK /lookup/doi/10.1158/1078-0432.CCR-11-1000 10.1158/1078-0432.CCR-11-1000 This?article?cites?112?articles,?50?of?which?you?can?access?for?free?at: HYPERLINK /content/18/1/64.full.html#ref-list-1 /content/18/1/64.full.html#ref-list-1 This?article?has?been?cited?by?2?HighWire-hosted?articles.?Access?the?articles?at: HYPERLINK /content/18/1/64.full.html#related-urls /content/18/1/64.full.html#related-urls HYPERLINK /cgi/alerts Sign? HYPERLINK /cgi/alerts up? HYPERLINK /cgi/alerts to? HYPERLINK /cgi/alerts receive? HYPERLINK /cgi/alerts free? HYPERLINK /cgi/alerts email-alerts?related?to?this?article?or?journal. To?order?reprints?of?this?article?or?to?subscribe?to?the?journal,?contact?the?AACR?Publications Department?at? HYPERLINK mailto:pubs@ pubs@. To?request?permission?to?re-use?all?or?part?of?this?article,?contact?the?AACR?Publications?Department?at HYPERLINK mailto:permissions@ permissions@. Downloaded?from? HYPERLINK / ?on?October?10,?2012 Copyright???2012? HYPERLINK / American? HYPERLINK / Association? HYPERLINK / for? HYPERLINK / Cancer? HYPERLINK / Research DOI:10.1158/1078-0432.CCR-11-1000 CCR?FOCUSHsp90?Molecular?Chaperone?Inhibitors:?Are?We?There CCR?FOCUS Len?Neckers1?and?Paul?Workman2 Abstract Heat?shock?protein?(Hsp)?90?is?an?ATP-dependent?molecular?chaperone?that?is?exploited?by malignant?cells?to?support?activated?oncoproteins,?including?many?cancer-associated?kinases?and transcription?factors,?and?it?is?essential?for?oncogenic?transformation.?Originally?viewed?with skepticism,?Hsp90?inhibitors?are?now?being?actively?pursued?by?the?pharmaceutical?industry,?with 17?agents?having?entered?clinical?trials.?Inve