病理学講義 免疫担当細胞.pptVIP

炎症に関る細胞群 急性炎症　acute inflammation Calor Tumor Rubor Ｄolor Functio laesa 血管内皮傷害 顆粒球による血管内皮破壊?transcytosisの亢進 好中球の活性化と血管外遊走 炎症に関る接着分子 好中球の活性化＝活性酸素 Oxygen-Independent Antimicrobial Activity Bactericidal permeability increasing protein (BPI)　causes　phospholipaseactivation, phospholipiddegradation and increased membrane permeability Lysozymecauses degradation of bacterial coat oliggosaccharides Major basic protein (MBP)is cytotoxiccomponent of eosinophilgranules Defensinsare pore-forming antibacterial peptides Germinal center の形成 Hashimoto disease Plasma　cell　形質細胞 Bリンパ球が分化した抗体産生細胞 核は偏在し、車軸核を形成 急性炎症末期から慢性炎症の病巣に出現 * * * 悪性腫瘍においては制御性T細胞関与が報告されていますが， * 妊娠でも制御性T細胞が重要なことが報告されています。 * Kuwana of Keio University who reported previously that , in patients with chronic immune thrombocytopenic purpura (IMTP), circulating T and B cells that are responsive to gpIIb-IIIa can induce anti-platelet autoantibody production. They examined the frequencies and activation status of gpIIb-IIIa-reactive T and B cells in PBMC and surgicallu resected splenic tissues. They observed the frequencies of anti-gpIIb-IIIa Ab-producing B cells, as determined by ELISPOT assay, were similar in peripheral blood and spleen however, an anti-gpIIb-IIIa Ab was spontaneously produced by splenocytes in vitro, but scarcely secreted by PBMCs. They concluded that an interaction between gpIIb-IIIa-reactive T and B cells inducing anti-platelet Ab production in IMTP patients occurs primarily in the spleen and that the significant number of gpIIb-IIIa-reactive T and B cells activated in the spleen are released into the circulation as memory cells. B細胞は飛道具（大砲）T細胞NK細胞は白兵戦 FasL TRAIL related apoptosis-inducing ligand)癌細胞にアポトーシスを誘導する事が、正常細胞には作用を示さない．但しHIV感染細胞では感受性となる Zhang L et al. Intratumoral T Cell s , Recurrence, and Survival in Epithelial Ovarian Cancer . N Engl J Med. 2003 Jan 16;348(3):203-13 卵巣癌186例において腫瘍内に浸潤したCD8陽性リンパ球数と予後を検討した．：　独立した予後因子である ヘルパーT細胞 　TCR?CD3複合体は、単球?マクロファージ表面の、抗原が結合したMHCクラスII分子を認