人血清vegf水平与血管性认知功能障碍的相关性分析-correlation analysis of vegf level in human serum with vascular cognitive impairment.docxVIP
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人血清vegf水平与血管性认知功能障碍的相关性分析-correlation analysis of vegf level in human serum with vascular cognitive impairment
wererelativelystable.3mlbloodwasadoptedfromelbowveinintheconditionofemptystomachinearlymorning,seperatingtheserumaftercentrifugating.ThenwecomparedthelevelofVEGFinserumamongthethreegroupsusingELISA.(2)Alldatawerepresentedasmean±standarddeviation.AstatisticalsignificancewasconsideredforP0.05.StatisticalevaluationwasdoneusingSPSS13.0statisticalanalysissoftware.Byhomogeneitytestofvariance,thedataofcontinuousvariableswasanalyzedusingANOVAifhomogeneityofvarianceorusingDunnettT3ifheterogeneityofvariance;thenumerationdatawasanalyzedusingchi-square.Results:TheserumcontentofVEGFinMVCIpatientswas5.31±11.49ng/ml,comparingwiththecontrols([(24.45±22.96)ng/ml]),thedifferentiationwasstisticallysignificant(P=0.001);TheserumcontentofVEGFinVDpatientswas9.00±15.66ng/ml,comparingwiththecontrols([(24.45±22.96)ng/ml]),thedifferentiationwasstisticallysignificant(P=0.011);therewasnostisticalsignificancebetweenMVCIandVD(P=0.648);thecoefficientcorrelationbetweenVEGFandagewas-0.029,P=0.785,therewasnostisticalsignificance;MMSEscores:MVCI:22.43±2.90,VD:11.55±5.38,controls:27.70±2.94,therewasstisticalsignificanceamonganytwoofthethree(P0.001);theage,sexandculturedegreewerenotdramaticallysignificantamongthethreegroups.Conclusion:ThelevelofVEGFinserumofVCIlowerthanthatofcontrolsshowedthatthedecreaseofVEGFhadcorrelationwiththegenesisanddevelopmentofVCI;thedeferentiationofVEGFhadnostisticalsignificancebetweenMVCIandVD.ThisshowedthatthelevelofVEGFhadnodramaticcorrelationwiththedegreeofVCI;andthelevelofVEGFhadnoobviouscorrelationwithage;theMMSEscoreswasthehighestincontrolgroup,andwasthelowestinVDgroup.ThisshowedthattheMMSEscoresweredecreasingastheVCIbecomemoreandmoreserious.TheaboveconclusionsprovidedtheoryaccordanceformechanismofgenesisanddevelopmentofVCIandusingectogenesisVEGFtocureVCI.KeyWords:vascularcognitiveimpairment;vascularendothelialgrowthfactor;serum;ELISA河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下,由本人独立完成。本学位论文研究所获的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文相关的论文,第一署名单位为河北医科大学,试验材料
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