球周注射壳聚糖甘油磷酸二钠对实验性白兔后巩膜加固作用-reinforcing effect of chitosan disodium glycerophosphate on posterior sclera of experimental white rabbits by peribulbar injection.docxVIP

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球周注射壳聚糖甘油磷酸二钠对实验性白兔后巩膜加固作用-reinforcing effect of chitosan disodium glycerophosphate on posterior sclera of experimental white rabbits by peribulbar injection.docx

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球周注射壳聚糖甘油磷酸二钠对实验性白兔后巩膜加固作用-reinforcing effect of chitosan disodium glycerophosphate on posterior sclera of experimental white rabbits by peribulbar injection

Measuringexperimentalanimals0h,24h,48h,72hbeforeeating,calculateweightchangeperday.3Aftersurgery2w,4w,6w,8wmeasureIOP,FFA,CT,A/B-ultrasonography.Rabbitswerekilledbyinjectingairembolisminearvein,injectedgentianviolet0.2mlcavityunderthefasciaofsurgicaleye,massagedeyeball,madegentianvioletliquidandchitosanglycerophosphatedisodiummixedfully.Afterfrozenrabbithead12h,alongrabbitsorbitalmadecoronalsectionandsagittalSectionwithself-madesmallsawblade,therestrabbitswereremovedeyeball,washedclean,Mixedscleraltissuewascut,thenakedeyeobservedfirstly,thenfixedwith10%formalinrespectively,usedparaffin-embedded、slice，HEstaining，lightmicroscopeobserved.Results:C/GPbiocompatibility:periorbitalinjectionofC/GPeyecausedmildinflammatoryresponse.Weightchangesofgroupscomparationwerenosignificantdifference(P0.05).intraocularpressuremeasurementresults:After2weeks,4weeks,8weeks,comparedbetween2weeksgroupandthecontrolgroup,thereisnostatisticaldifferenceinthelefteyeIOP(P0.05).Withthecontrolgroup,intraocularpressureof4weeks,8weeksincreased,andthetwogroupswerestatisticaldifference(P0.05).Comparedwith2weeks,intraocularpressureof8-weekgroupincreased,werestatisticallysignificantdifference(P0.05).Comparedwith4weeks,intraocularpressureof8-weekgroupincreased,existedstatisticallysignificantdifference(P0.05).Comperaionof2,4,8weeks,therighteyeofthethreegroupswerenotstatisticallysignificantcomparedintraocularpressure(P＞0.05).axiallengthmeasurements:Comparedwiththecontrolgroup,axiallengthofoperationgroupswerenosignificantdifference(P0.05).Comparedwithaxiallengthofthelefteyeofrabbitsin2,4,8weekswerenosignificantdifference(P0.05),comparedwithaxiallengthoftherighteyeofrabbitsin2,4,8weekswerenosignificantdifference(P0.05),leftandrighteyeofrabbitsin2,4,8weekswerenosignificantdifferencebetweenaxial(P0.05).orbitalCTexaminationresults:Comparedwithlefteyeofcontrolgroup,scleraoflefteyeovertheposteriorpolepartialtemporalofrabbitsin2weeksweresignificantthickening,formedaannular“newsclera”,thenewsclerawasuniformdensity,w