球形木质素树脂对两种生物碱吸附的初步分析-preliminary analysis of adsorption of two alkaloids by spherical lignin resin.docxVIP

球形木质素树脂对两种生物碱吸附的初步研究摘要生物碱是一类非常重要的天然有机化合物，大多具有较强的生物活性，是很多药物的先导化合物，已成为药物研究的一个重点。随着生物碱的应用不断扩大，它的提取分离已成为制约其发展的一个重要因素。就目前的分离方法而言，吸附法仍是得到生物碱的最主要的方法。木质素树脂作为一种廉价且原材料来源丰富的吸附剂，其应用范围也在不断的扩大，因此本文采用一种新型的球形木质素树脂对生物碱的吸附行为进行了研究。采用静态吸附法研究了木质素树脂对生物碱的吸附性能，考察了时间、浓度等因素对吸附效果的影响，进行了其热力学和动力学的研究及解吸再生能力的实验。结果表明：球形木质素树脂对次乌头碱和苦参碱均具有良好的吸附效果。对次乌头碱和苦参碱在303K时的吸附容量分别为47.0mg/g和55.6mg/g，且吸附容量随吸附质溶液的浓度和吸附时间增长而升高。静态吸附等温曲线符合Langmuir和Freundlich吸附等温方程式，并且对生物碱的吸附以化学吸附为主，吸附过程的限速步骤受表面扩散和颗粒内扩散共同控制，主要以颗粒内为主。球形木质素树脂具有较好的解吸再生和重复利用的能力。球形木质素树脂具有原材料丰富易得、吸附性能好、再生能力强等特点。球形木质素树脂的应用有利于制浆黑液的有效利用，减少污染，降低生物碱的分离成本，因此有着广泛的应用前景。关键词：球形木质素树脂；吸附；分离；次乌头碱；苦参碱；热力学；动力学StudyontheAdsorptionBehaviorsoftwoalkaloidsontheSphericalLigninResinAbsorbentAbstractAlkaloidsareakindofveryimportantnaturalorganiccompounds,mostlywithstrongbiologicalactivity,andtheyareleadcompoundsofmanydrugs.Now,theyhavebecomeakeypointofdrugresearch.Withtheexpandingapplicationofthealkaloids,themethodsofextraction,separationandpurificationhavebecomearestrictionfactortoalkaloidsdevelopment.Itisthetruththatadsorptionisoneofthemostpopularmethodsduringthealkaloidsseparationandpurification.Asaninexpensiveandpracticalutilityadsorbent,theapplicationscopeofligninresinadsorbentbecomeswiderowingtoitsabundantrawmaterials.Consequently,anovelsphericalligninresinadsorbentwaspreparedtoconducttheresearchontheadsorptionperformancebyusingtwoalkaloidsasadsorbates.Theadsorptionpropertiesofthesphericalligninresinabsorbentwerestudiedinwayofstaticadsorption.And,theeffectfactors:time,concentration,etc.werealsooptimized.Moreover,theadsorptionmechanisms,i.e.,theadsorptionthermodynamicsandkineticswereconducted.Thedesorptionandregenerativecapacitytestsaswellascomparisonexperimentswereinspected.Theresultsshowthat:sphericalligninresinabsorbenthasagoodadsorptionefficiencyforHypaconitineandMatrine.Theadsorptioncapacitiescanreach47.0mg/gand55.6mg/g,respectively,in303K.Andthecapacitywaspositivelycorrelatedwithconcentrationandtime.TheadsorptionisothermcurveofstaticadsorptionprocessesfollowedtheLangmu