桂枝茯苓胶囊配伍米非司酮治疗绝经前期子宫肌瘤疗效观察.docVIP

桂枝茯苓胶囊配伍米非司酮治疗绝经前期子宫肌瘤疗效观察 　　摘要：目的：探讨桂枝茯苓胶囊配伍米非司酮治疗绝经前期子宫肌瘤的临床疗效与安全性。方法：将120例绝经前期子宫肌瘤患者随机分为观察组与对照组，每组各60例。对照组予以米非司酮片，观察组在对照组的基础上，非经期口服桂枝茯苓胶囊，连续使用3个月，治疗结束后随访6个月。观察各评价指标、患者主观不良感受或副作用。结果：治疗后观察组与对照组患者的子宫肌瘤平均体积均较治疗前缩小，缩小率分别为60.0%、44.30%，总有效率分别为95.00%、83.30%，随访6个月观察组子宫肌瘤反弹率低于对照组，差异均具有统计学意义（P＜0.05），但两组不良反应比较，差异无统计学意义（P＞0.05）。结论：桂枝茯苓胶囊配伍米非司酮治疗绝经前期子宫肌瘤具有较高的临床有效率，明显缓解了患者的临床症状，复发反弹率低，远期疗效确切，且未见明显的不良反应???可能是一种较为优化的治疗方案，值得临床推广应用。 　　关键词：子宫肌瘤；米非司酮；桂枝茯苓胶囊；活血化瘀 　　中图分类号：R711.74文献标识码：B文章编号：1673-7717(2012)03-0665-03 　　 　　Curative Effects on Treating Premenopause Hysteromyoma by 　　Mifepristone with Guizhi Fuling Capsule 　　MAO Chun?xian，CAI Rong?rong，WANG Xiu?ping，WU Xiao?ling 　　(Jiande Maternity and Child Care Hospital, Jiande City, Zhejiang Province 311600) 　　Abstract:Objectives:To explore the curative effects and safety of treating premenopause hysteromyoma by mifepristone with Guizhi Fuling Capsule. Methods:120 cases with premenopause hysteromyoma were randomly divided into observation group and control group, 60 cases in each group. Patients in control group were given mifepristone, and patients in observation group were given cassia twig- poria cocos capsule on the basis of control group during non-menstrual period. All cases were treated for 3 months, and were followed up for 6 months later after treatment, and evaluation index, subjective negative feelings or side effects were recorded. Results:Hysteromyomas average volume in the two groups were all reduced after treatment, and the reduction rates were 60.0% and 44.30% respectively, and the total effective rates were 95.00% and 83.30% respectively, and rebound rate in observation group was lower than that in control group 6 months later after follow up, and there were statistically significant differences (P0.05). Conclusions:It had high curative effects on treating premenopause hysteromyoma by mifepristone with cassia twig- poria cocos capsule, and it obviously reduced clinical symptoms and rebound rate, and the long-t