il 17 il 23在慢性荨麻疹患者外周血中的表达及意义-expression and significance of il 17 il 23 in peripheral blood of patients with chronic urticaria.docx

本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经 发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式 标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并 向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华 中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影 印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于必威体育官网网址□ ，在年解密后适用本授权书。不必威体育官网网址□（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日中文摘要·········································································································1英文摘要·········································································································2 前言················································································································· 3 资料和方法···································································································· 4结果与分析···································································································· 7 讨论················································································································· 9 结论················································································································· 13 参考文献·········································································································13 综述················································································································· 17 致谢················································································································· 31IL-17、IL-23 在慢性荨麻疹患者外周血中的表达及意义中文摘要【目的】 检测慢性荨麻疹患者外周血中白介素（IL）-17、IL-23 表达水平的变化， 探讨 Th17 细胞在慢性荨麻疹发病中的作用。【方法】采用酶联免疫吸附试验方法（ELISA）检测 30 例慢性荨麻疹患者血清中 IL-17 和 IL-23 的表达水平，与 30 例健康对照组进行比较，并对这两个细胞因子的相关性 进行分析。【结果】慢性荨麻疹患者外周血中 IL-17、IL-23 的浓度水平分别是（403.43±141.61） pg/ml、（243.52±91.86）pg/ml ，而正常对照组 IL-17、IL-23 的浓度分别为（58.31±36.32）pg/ml、（36.52±26.21）pg/ml，IL-17、IL-23 在慢性荨麻疹患者组外周血 中的表达水平较正常对照组显著升高，差异有统计学意义(P0.05)，并且慢性荨麻疹 患者外周血中 IL-17 与 IL-23 的表达水平具有明显相关性，呈正相关。【结论】 IL-17、IL-23 在慢性荨麻疹患者外周