il 10基因启动子 1082ag多态性与自身免疫性疾病易感性的荟萃分析-meta - analysis of il 10 gene promoter 1082 ag polymorphism and susceptibility to autoimmune diseases.docx

独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成 果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或 集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文 中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保 留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本 人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索， 可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于必威体育官网网址□，在年解密后适用本授权书。不必威体育官网网址□。（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录中文摘要········································································································· 1Abstract 2前言················································································································· 4 资料与方法····································································································· 6 结果················································································································· 8讨论··············································································································· 19结论··············································································································· 21 参考文献······································································································· 22 综述··············································································································· 27 参考文献······································································································· 39 致谢··············································································································· 45IL-10 基因启动子-1082A/G 多态性与自身免疫性疾病易感性的荟萃分析 学位申请人：刘志芬 导师：胡绍先中文摘要目的：运用荟萃分析的方法探讨 IL-10 基因启动子-1082A/G 多态性与自身免疫性疾病 易感性的相关性。 方法：检索相关文献，纳入符合标准的病例对照研究，建立合适的遗传学比较模型， 利用软件计算比值比（OR）与 95%可信区间（CI），并进行相关性分析。 结果：总共纳入 20 篇文献，共计 3551 名自身免疫性疾病患者和 4721 名健康对照者。 在东方人群亚组分析中，四个基因模型比较（AA vs GG：OR= 0.40，95% CI=0.25~0.64； GA vs GG：OR=0.44，95% CI=0.28~0.69；AA/AG vs GG ：OR= 0.42，95% CI=0.27~0.65；AA vs GA/GG：OR= 0.79，95% CI=0.63~1.00），结果发现 IL-10 基因启动子-1082A/G 多态性与自身免疫性疾病易感性存在显著相关性；