hmgb1与tlr2 tlr4在类风湿关节炎中的表达及作用机制分析-expression and mechanism analysis of hm gb1 and tlr 2ttl r4 in rheumatoid arthritis.docx

Conclusion The level of HMGB1 in serum can be used as an indicator of RA disease activity.The expression of HMGB1 and TLR2/TLR4 in RA was increased and they were associated with the occurrence and development of RA. HMGB1/TLR pathway may be an important inflammatory start factor in the pathogenesis of RA.Key wordsArthritis, rheumatoid, HMGB1, TLRs英文缩写缩略词表英文译名中文全称ACR APC CRP DEPC DNA EDTA ELISA ESR FCM FITCFRETAmerican College of Rheumatology allophycocyaninc reactive protein diethypyrocarbonate deoxyribonucleic acid ethylenediamine tetra-acetic acid enzyme linked immunosorbent assay erythrocyte sedimentation rateflow cytometry fluorescein isothiocyanatefluorescence resonance energy transfer美国风湿病协会 别藻青蛋白 C反应蛋白 焦碳酸二乙酯 脱氧核糖核酸 乙二胺四乙酸 酶联免疫吸附试验 红细胞沉降率 流式细胞术 异硫氰酸荧光素 荧光共振能量转移HMGB1high mobility group boxchromosomal protein l高迁移率族蛋白1HRP IL-1 IL-1R IRAK LBP LPSh HSP LRRMAPKMFIhorseradish peroxidase interleukin-1 Interleukin-1 ReceptorIL-1 receptor associated kindase LPS binding protein lipopolysaccharidehourhot shock protein Leucine-rich repeatmitogen-activated protein kinasemean fluorescence index辣根过氧化物酶白细胞介素-1 白介素1受体IL-1受体相关的激酶LPS结合蛋白 脂多糖小时热休克蛋白 富含亮氨酸的重复序列 丝裂原活化蛋白激酶 平均荧光指数MyD88myeloid differentiation factor88髓系分化因子88NCBINational Center of BiotechnologyInformation国家生物技术信息中心NF-κBnuclear factor-κB核因子-κBPAMPPBMCpathogen associated molecular patternsperipheral blood mononuclear cell病原相关分子模式外周血单个核细胞PE RAphycoerythrin rheumatoid arthritis藻红蛋白类风湿关节炎RAGERF RNAreceptor for advanced glycation end products rheumatoid factorribonucleic acid晚期糖基化终产物受体 类风湿因子核糖核酸RNasinribonucleaseinhibitorRNA酶抑制剂rpmrevolutions per minute转/分RT-PCRreverse transcriptionpolymerase chain reaction逆转录聚合酶链反应ssecond秒SPSSstatistical package for thesocial scienceSPSS统计软件包TAK1Transforming growth factoractivated kinase l转化生长因子活化的激酶1TILToll/IL-1 homologous regionToll/IL-1受体同源区TLRsToll-like receptorsToll样受体TNF-α TRAFtumor necrosis factor alphaTNF-α Receptor association factor肿瘤坏死因子-α 肿瘤坏死因子受体相关因子学位论文独创性声明本人声明，所呈交的学位论文系