hla审审dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-study on the association between hla - dqa 1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection.docx

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hla审审dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-study on the association between hla - dqa 1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection.docx

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hla审审dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-study on the association between hla - dqa 1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection

ASC group was found（p = 0.312, 0.308, 0.264 ）；After adjusted for age and sex, therewere also no significant differences between the case and control group.when the genotype GG plus GA versus genotype AA. We stratified the case-control study by sex factor and found that the the genotype GG plus GA was a protective factor for progression to acute-on-chronic liver failure compared to genotype AA in female patients（OR=0.3,95%CI:0.10~0.87）③.As for the rs7271350 polymorphism in SNX5 gene, astatistically significant association with susceptibility to acute hepatic failure was observed with the C allele(P=0.035). Subjects bearing at least one C allele(genotype CC plus CT) had an increased susceptibility to acute hepatic failure compared to those bearing TT genotype(OR=1.876;95%CI:1.064~3.307,P=0.030)with adjustment for age and sex. However no significant associations were found between the genotype and the occurring of liver cirrhosis or hepatocellular carcinoma.Conclusion①Male, HBeAg positive chronic HBV infected patients are more susceptible to progress to acute liver failure. ② The single nucleotide polymorphism of rs9272346 locus in HLA-DQA1 gene may have no associations with different outcomes of chronic hepatitis B virus infection. While the genotype GG and GA may be the protective factor for progression to acute-on-chronic liver failurein female patients.③ The subjects bearing at least one C allele of rs7271350 in SNX5 gene may have higher risk for progression to acute-on-chronic liver failurecompared to TT genotype.Key wordsChronic hepatitis B virus infection; clinical outcomes; single nucleotide polymorphism; HLA-DQA1 gene; SNX5 gene英文缩略词英文缩写英文名称中文名称SNPSingle nucleotide polymorphism单核苷酸多态性HLA-DQA1Human leukocyte antigen, DQ alpha 1人类白细胞抗原 DQA1SNX5Sorting nexin 5分类连接蛋白 5HBVHepatitis B virus乙型肝炎病毒HBsAgHepatitis B virus surface antigen乙肝表面抗原DNADeoxyribonucleic acid脱氧核糖核酸HBeAgHepatitis B virus antigen乙肝 e 抗原HBsAbHepatitis B virus surface antibody乙肝表