hla dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-association between hla dqa1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection.docx

下载文档 降价啦

7
0
约4.01万字
约 37页
2018-05-29 发布于上海
举报
版权申诉
保障服务

hla dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-association between hla dqa1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection.docx

1、本文档共37页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

hla dqa1基因rs9272346和snx5基因rs7271350多态性与慢性hbv感染不同转归的关联性研究-association between hla dqa1 gene rs 9272346 and snx 5 gene rs 7271350 polymorphism and different outcomes of chronic hbv infection

【结论】①男性和 HBeAg 阳性的慢性 HBV 感染者更易表现为进展性肝炎。②HLA-DQA1 基因 rs9272346 位点单核苷酸多态性可能与乙型肝炎不同转归无相关性。而女性患者中 G 等位基因携带可能是进展为重型肝炎的保护因素。③SNX5 基因 rs7271350 位点 C 等位基因与重型肝炎发生相关，C 等位基因携带者相对于 TT 基因型是进展为重型肝炎的危险因素。【关键词】慢性 HBV 感染，临床转归；单核苷酸多态性；HLA-DQA1 基因；SNX5 基因Associations of rs9272346 polymorphism in HLA-DQA1 gene and rs7271350 polymorphism in SNX5 gene with diverse clinical outcomes of chronic HBV infectionObjectiveAbstractHepatitis B virus(HBV) infection is a complicated disease caused by virus, multigenes and enviroment factor. Its an useful strategy to determine potential candidate genes of HBV infection for the prevention and individualized treatment. The purpose of this study is to evaluate the distribution differences of rs9272346 polymorphism in HLA-DQA1 and rs7271350 polymorphism in SNX5 gene in Han population of Hubei province, to explore the association of rs9272346 polymorphism in HLA-DQA1 and rs7271350 polymorphism in SNX5 gene with the different outcomes of chronic hepatitis B virus infection in Hubei Han people.MethodsA case-control study was conducted, 798 unrelated chronic HBV infection subjects with progressed outcomes and 236 unrelated chronic asymptomatic HBV carriers as controls were recruited in Han population of Hubei province from Wuhan Tongji Hospital. The 798 patients in the case group were divided into the acute-on-chronic liver failure(ACLF) group, HBV-related liver cirrhosis(LC) group and HBV-related hepatocellular carcinoma(HCC) group.We obtained the blood samples, and collected the materials of medical history and laboratory test results.Using the genome DNA as templates, the genotypes of rs9272346 and rs7271350 were determinated by real-time polymerase chain reaction with the Taqman MGB probe. The statistical data was analyzed by students t test ,chi square test and unconditional logistic regression.Results①Clinical data shows that the proportion of men and HBeAg positive patients in each case group is higher than that in the control group（ p 0.01 ）.② For